Tapasin-related protein (TAPBPL) is a 468-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9BX59.
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The mean pLDDT of this model is 79.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 47% |
| 70 to 90 | Confident: backbone generally right | 27% |
| 50 to 70 | Low: treat with caution | 10% |
| Below 50 | Very low: often disordered regions | 17% |
What pLDDT means and how to read it
Component of the antigen processing and presentation pathway, which binds to MHC class I coupled with beta2-microglobulin/B2M. Association between TAPBPR and MHC class I occurs in the absence of a functional peptide-loading complex (PLC)
Interacts with peptide-free HLA-A*02-B2M complexes or those loaded with low affinity peptides, likely facilitating peptide exchange onto higher affinity peptides (PubMed:26869717, PubMed:35725941). Interacts with MR1 in a ligand-independent way; this interaction may stabilize MR1 pool and facilitate ligand loading and dissociation (PubMed:32958637, PubMed:35725941)
Cell membrane, Endoplasmic reticulum membrane, Microsome membrane, Golgi apparatus membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9C96 | EM | 3.0 Å | C=22-405 |
| 5WER | X-ray | 3.41 Å | C/F/I/L=22-410 |
| 7RNO | NMR | C=22-405 |
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