WW domain-containing transcription regulator protein 1 (Wwtr1) is a 395-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9EPK5.
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The mean pLDDT of this model is 58.6 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 10% |
| 70 to 90 | Confident: backbone generally right | 20% |
| 50 to 70 | Low: treat with caution | 19% |
| Below 50 | Very low: often disordered regions | 51% |
What pLDDT means and how to read it
Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:11118213, PubMed:37215988). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (By similarity). WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation (By similarity). In conjunction with YAP1, involved in the…
Binds to SLC9A3R2 via the PDZ motif at the plasma membrane (PubMed:11118213). Binds to YWHAZ in vivo and in vitro through the phosphoserine-binding motif RSHSSP (PubMed:11118213). Interacts (via coiled-coil domain) with SMAD2 (via MH1 domain), SMAD3 and SMAD4 (By similarity). Interacts with MED15 (By similarity). Interacts with PAX8 and NKX2-1 (By similarity). Interacts with TEAD1, TEAD2, TEAD3…
Nucleus, Cytoplasm, Cell membrane, Cell junction, tight junction
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5GN0 | X-ray | 2.9 Å | E/F/G/H=24-57 |
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