Toll-like receptor 9 (Tlr9) is a 1032-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9EQU3.
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The mean pLDDT of this model is 87.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 68% |
| 70 to 90 | Confident: backbone generally right | 20% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 6% |
What pLDDT means and how to read it
Key component of innate and adaptive immunity (PubMed:31408613). TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms (PubMed:31408613). TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides (PubMed:31408613). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:14993594, PubMed:17474149, PubMed:18820679, PubMed:18931679, PubMed:21402738, PubMed:25686612). Also acts via ADCY7, leading to cyclic di-AMP (c-di-AMP) synthesis and activation of the NLRP3 inflammasome…
Monomer and homodimer. Exists as a monomer in the absence of unmethylated cytidine-phosphate-guanosine (CpG) ligand. Proteolytic processing of an insertion loop (Z-loop) is required for homodimerization upon binding to the unmethylated CpG ligand leading to its activation (By similarity). Interacts with MYD88 via their respective TIR domains (PubMed:18820679). Interacts with BTK (By similarity).…
Endoplasmic reticulum membrane, Endosome, Lysosome, Cytoplasmic vesicle, phagosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3WPF | X-ray | 1.96 Å | A=26-818 |
| 3WPG | X-ray | 2.25 Å | A=26-818 |
| 3WPI | X-ray | 2.25 Å | A=26-818 |
| 5ZLN | X-ray | 2.3 Å | A/B=26-818 |
| 3WPH | X-ray | 2.33 Å | A=26-818 |
| 4QDH | X-ray | 2.4 Å | A/B=478-753 |
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