E3 ubiquitin-protein ligase RNF38 (RNF38) is a 515-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9H0F5.
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The mean pLDDT of this model is 52.5 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 14% |
| 70 to 90 | Confident: backbone generally right | 4% |
| 50 to 70 | Low: treat with caution | 12% |
| Below 50 | Very low: often disordered regions | 70% |
What pLDDT means and how to read it
Acts as an E3 ubiquitin-protein ligase able to ubiquitinate p53/TP53 which promotes its relocalization to discrete foci associated with PML nuclear bodies. Exhibits preference for UBE2D2 as a E2 enzyme
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9Q88 | X-ray | 1.2 Å | A=439-515 |
| 4V3L | X-ray | 1.53 Å | C=439-515 |
| 4V3K | X-ray | 2.04 Å | C/F=439-515 |
| 7OJX | X-ray | 2.4 Å | A=439-515 |
| 9Q8Y | X-ray | 2.63 Å | C/D=440-508 |
| 1X4J | NMR | A=445-506 |
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