Ras-related protein Rab-1B (RAB1B) is a 201-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9H0U4.
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The mean pLDDT of this model is 85.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 69% |
| 70 to 90 | Confident: backbone generally right | 12% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 12% |
What pLDDT means and how to read it
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:20545908, PubMed:9437002, PubMed:23236136). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:9437002). Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum (PubMed:20545908). Regulates vesicular transport between the endoplasmic reticulum and successive Golgi…
Interacts with MICAL1 and MICAL2 (PubMed:15694364, PubMed:27552051). Interacts (in GTP-bound form) with MICALCL, MICAL1 and MILCAL3 (PubMed:15694364, PubMed:27552051). Interacts with GDI1; the interaction requires the GDP-bound state (PubMed:11389151, PubMed:8836150). Interacts with CHM/REP1; the interaction requires the GDP-bound form and is necessary for prenylation by GGTase II…
Cytoplasm, Membrane, Preautophagosomal structure membrane, Cytoplasm, perinuclear region
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3NKV | X-ray | 1.7 Å | A/B=3-174 |
| 3JZA | X-ray | 1.8 Å | A=3-174 |
| 8ALK | X-ray | 2.15 Å | B=3-174 |
| 5SZH | X-ray | 2.3 Å | B=1-201 |
| 5O74 | X-ray | 2.5 Å | B/D/F/H/J/L=3-174 |
| 4I1O | X-ray | 2.7 Å | A/C/E/G=3-174 |
| 5SZK | X-ray | 2.8 Å | B=1-201 |
| 6SKU | X-ray | 3.2 Å | B=3-174 |
| 4HLQ | X-ray | 3.3 Å | B/D/F/H/J=3-174 |
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