Small conductance calcium-activated potassium channel protein 2 (KCNN2) is a 579-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9H2S1.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 76.5 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 43% |
| 70 to 90 | Confident: backbone generally right | 30% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 23% |
What pLDDT means and how to read it
Small conductance calcium-activated potassium channel that mediates the voltage-independent transmembrane transfer of potassium across the cell membrane through a constitutive interaction with calmodulin which binds the intracellular calcium allowing its opening (PubMed:10991935, PubMed:33242881, PubMed:9287325). The current is characterized by a voltage-independent activation, an intracellular calcium concentration increase-dependent activation and a single-channel conductance of about 3 picosiemens (PubMed:10991935). Also presents an inwardly rectifying current, thus reducing its already small outward conductance of potassium ions, which is particularly the case when the membrane…
Homodimer (PubMed:20689065). Heteromultimer with KCNN1 and KCNN3 (PubMed:20689065, PubMed:9287325). The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding (By similarity). Interacts (via N-terminal domain) with MPP2 (By similarity)
Membrane, Cytoplasm, myofibril, sarcomere, Z line
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5V03 | X-ray | 1.58 Å | B=395-486 |
| 5V02 | X-ray | 1.78 Å | B=395-486 |
| 5WBX | X-ray | 1.9 Å | B=395-486 |
| 5WC5 | X-ray | 2.3 Å | B=395-486 |
| 6ALE | X-ray | 2.5 Å | B=394-486 |
| 9ZRQ | EM | 2.77 Å | A/B/C/D=117-477 |
| 9VUC | EM | 2.96 Å | A/B/C/D=1-579 |
| 9O48 | EM | 3.1 Å | A/B/C/D=125-412 |
| 9O5O | EM | 3.1 Å | A/B/C/D=125-412 |
| 9O52 | EM | 3.18 Å | A/B/C/D=125-412 |
| 9VUA | EM | 3.23 Å | A/B/C/D=1-579 |
| 9O53 | EM | 3.3 Å | A/B/C/D=125-412 |
| 9VU9 | EM | 3.34 Å | A/B/C/D=1-579 |
| 9VUB | EM | 3.35 Å | A/B/C/D=1-579 |
| 9O51 | EM | 3.4 Å | A/B/C/D=125-412 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.