F-box only protein 44 (FBXO44) is a 255-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9H4M3.
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The mean pLDDT of this model is 92.4 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 81% |
| 70 to 90 | Confident: backbone generally right | 14% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Substrate-recognition component of two distinct E3 ligase complexes, the SKP1-CUL1-FBXO44 complex and the CUL4B-DDB1-FBXO44 complex (PubMed:18203720, PubMed:25970626). The complex SCF(FBXO44) complex ubiquitinates and mediates BRCA1 degradation (PubMed:23086937). In association with cullin 4B/CUL4B and DDB1, mediates the ubiquitination of RGS2 leading to its degradation (PubMed:25970626). Additionally, regulates the pregnane X receptor/NR1I2 protein level by ubiquitination and degradation (PubMed:37969738)
Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with SKP1 and CUL1. Interacts with CUL4B and DDB1 (PubMed:25970626). Interacts wwith BRCA1; this interaction mediates BRCA1 ubiquitination and subsequent degradation (PubMed:23086937). Interacts with RGS2; this interaction mediates RGS2 ubiquitination and subsequent degradation (PubMed:25970626). Interacts with PXR/NR1I2; this…
Nucleus
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