Probable ATP-dependent RNA helicase DHX35 (DHX35) is a 703-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9H5Z1.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 86.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 64% |
| 70 to 90 | Confident: backbone generally right | 27% |
| 50 to 70 | Low: treat with caution | 2% |
| Below 50 | Very low: often disordered regions | 7% |
What pLDDT means and how to read it
Acts as a co-sensor in RIGI-mediated antiviral innate immunity (PubMed:39037956). Enhances RIGI recognition of viral nucleic acids and interacts with RIGI and MAVS to form a signaling complex which triggers downstream signaling cascades that lead to the induction of type I interferons and pro-inflammatory cytokines during the antiviral innate immune response (PubMed:39037956)
Identified in the spliceosome C complex (PubMed:11991638). Interacts (via helicase C-terminal domain) with RIGI and MAVS to form a signaling complex upon viral infection (PubMed:39037956)
Nucleus, Cytoplasm
UniProt lists no experimental PDB structure for this protein, so the AlphaFold prediction is the main 3D model available.
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.