5-azacytidine-induced protein 2 (AZI2) is a 392-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9H6S1.
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The mean pLDDT of this model is 68.6 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 37% |
| 70 to 90 | Confident: backbone generally right | 11% |
| 50 to 70 | Low: treat with caution | 16% |
| Below 50 | Very low: often disordered regions | 37% |
What pLDDT means and how to read it
Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity (PubMed:14560022, PubMed:21931631). Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization (PubMed:14560022, PubMed:21931631). Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1 (PubMed:14560022, PubMed:21931631). Promotes TBK1-induced as well as TNF or PMA-induced activation of NF-kappa-B (PubMed:14560022, PubMed:21931631). Participates in IFNB promoter activation via TICAM1 (PubMed:15611223)
Homodimer (By similarity). Interacts with IKBKE (PubMed:14560022, PubMed:17568778). Interacts with TBK1 (PubMed:14560022, PubMed:21931631, PubMed:29251827). Interacts with TICAM1 (PubMed:15611223). Interacts with TAX1BP1 (PubMed:30459273). Interacts with CALCOCO2 (PubMed:30459273)
Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5EP6 | X-ray | 1.45 Å | A/C=215-255 |
| 5Z7L | X-ray | 2.02 Å | C/D=33-75 |
| 7EA2 | X-ray | 2.14 Å | A/B=6-16 |
| 5Z7G | X-ray | 2.3 Å | C/D=33-75 |
| 7EA7 | X-ray | 2.69 Å | C=6-16 |
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