5' exonuclease Apollo (DCLRE1B) is a 532-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9H816.
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The mean pLDDT of this model is 74.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 58% |
| 70 to 90 | Confident: backbone generally right | 6% |
| 50 to 70 | Low: treat with caution | 2% |
| Below 50 | Very low: often disordered regions | 34% |
What pLDDT means and how to read it
5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres that are vulnerable to end-joining reactions and expose the telomere end in a manner that activates the DNA repair pathways.…
Interacts with TERF2; the interaction is direct (PubMed:16606622, PubMed:16730175, PubMed:16730176, PubMed:18468965, PubMed:18593705, PubMed:20655466, PubMed:35007328). Interacts with MUS81, MRE11 and FANCD2 (PubMed:18469862). Interacts with HSPA2, HSPA8 and HSPA14 (PubMed:19411856). Interacts with SPAG5 (PubMed:19197158)
Chromosome, telomere, Nucleus, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7A1F | X-ray | 1.8 Å | A/L=1-335 |
| 5AHO | X-ray | 2.16 Å | A=1-335 |
| 3BUA | X-ray | 2.5 Å | E/F/G/H=495-530 |
| 7B9B | X-ray | 2.8 Å | A=1-335 |
| 7B2X | X-ray | 3.1 Å | A=2-335 |
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