Ankyrin repeat family A protein 2 (ANKRA2) is a 313-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9H9E1.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 67.4 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 48% |
| 70 to 90 | Confident: backbone generally right | 5% |
| 50 to 70 | Low: treat with caution | 10% |
| Below 50 | Very low: often disordered regions | 38% |
What pLDDT means and how to read it
May regulate the interaction between the 3M complex and the histone deacetylases HDAC4 and HDAC5 (PubMed:25752541). May also regulate LRP2/megalin (By similarity)
Interacts (via ANK repeats) with CCDC8 (via PxLPxI/L motif); mediates the interaction with the 3M complex which is composed of CCDC8, CUL7 and OBSL1 (PubMed:25752541). Interacts (via ANK repeats) with HDAC4 (via PxLPxI/L motif) (PubMed:22649097). Interacts (via ANK repeats) with HDAC5 (via PxLPxI/L motif) (PubMed:22649097). Interacts (via ANK repeats) with LRP2/megalin (via PxLPxI/L motif)…
Cytoplasm, cytoskeleton, Membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3V31 | X-ray | 1.57 Å | A=148-313 |
| 4LG6 | X-ray | 1.8 Å | A=142-313 |
| 3V2X | X-ray | 1.85 Å | A=148-313 |
| 3V2O | X-ray | 1.89 Å | A=148-313 |
| 3SO8 | X-ray | 1.9 Å | A=149-310 |
| 4QQI | X-ray | 2.03 Å | A=142-313 |
| 8CXG | EM | 3.2 Å | A/B/C=1-135 |
| 8CXH | EM | 3.2 Å | A/B/C=1-135 |
| 8CXI | EM | 3.4 Å | A/B/C=1-135 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.