Transcription factor IIIB 50 kDa subunit (BRF2) is a 419-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9HAW0.
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The mean pLDDT of this model is 84.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 67% |
| 70 to 90 | Confident: backbone generally right | 13% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 13% |
What pLDDT means and how to read it
General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites (PubMed:11040218, PubMed:11121026, PubMed:11564744, PubMed:26638071). Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress (PubMed:26638071). Down-regulates expression of target genes in response to oxidative stress (PubMed:26638071). Overexpression protects cells against apoptosis in response to oxidative stress (PubMed:26638071)
Component of TFIIIB complexes. The TFIIIB complex has two activities, alpha and beta. The TFIIIB-alpha activity complex is composed of TBP, BDP1, and a complex containing both BRF2 and at least four stably associated proteins; this complex inhibits the transcription by pol III via its phosphorylation by CK2; YY1 facilitates the TFIIIB-alpha complex formation. Interacts with TBP; this interaction…
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4ROC | X-ray | 1.9 Å | A=62-419 |
| 4ROE | X-ray | 2.2 Å | A=62-419 |
| 4ROD | X-ray | 2.7 Å | A=62-419 |
| 5N9G | X-ray | 2.7 Å | A/F=62-419 |
| 9K39 | EM | 2.8 Å | V=1-419 |
| 9K36 | EM | 2.9 Å | V=1-419 |
| 9K2G | EM | 3.0 Å | V=1-419 |
| 9K3U | EM | 3.0 Å | V=1-419 |
| 9K38 | EM | 3.1 Å | V=1-419 |
| 9FSO | EM | 3.28 Å | S=1-419 |
| 9LXN | EM | 3.3 Å | V=1-419 |
| 9FSP | EM | 3.39 Å | S=1-419 |
| 8IUH | EM | 3.4 Å | V=1-419 |
| 9K3V | EM | 3.5 Å | V=1-419 |
| 9LKT | EM | 3.5 Å | V=1-419 |
| 9FSQ | EM | 3.51 Å | S=1-419 |
| 9LXO | EM | 3.6 Å | V=1-419 |
| 9FSR | EM | 3.76 Å | S=1-419 |
| 8ITY | EM | 3.9 Å | V=1-419 |
| 8IUE | EM | 4.1 Å | V=1-419 |
Showing 20 of 22 experimental structures (best resolution first).
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