Histone-lysine N-methyltransferase PRDM16 (PRDM16) is a 1276-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9HAZ2.
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The mean pLDDT of this model is 50.8 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 0% |
| 70 to 90 | Confident: backbone generally right | 27% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 65% |
What pLDDT means and how to read it
Transcription regulator that acts both as a histone methyltransferase or chromatin adapter, depending on the context (PubMed:12816872). In the cytoplasm, acts as a histone methyltransferase, which catalyzes monomethylation of 'Lys-9' of free histone H3 (H3K9me1) during translation (By similarity). Monomethylated histone H3 is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases (SUV39H1 and SUV39H2) use it as a substrate to catalyze histone H3 'Lys-9' trimethylation (H3K9me3) (By similarity). Probably one of the primary histone methyltransferases along with MECOM/PRDM3 that direct cytoplasmic H3K9me1 methylation (By similarity). In the nucleus,…
Interacts with CEBPA, CEBPB and CEBPD; the interaction is direct (By similarity). Interacts with PPARG; controls brown adipocytes (By similarity). Interacts with CTBP1 and CTBP2; represses the expression of white adipose tissue-specific genes (By similarity). Interacts (via N-terminus) with RBBP4 (PubMed:30462309). Interacts with PPARGC1A and PPARGC1B; interaction with PPARGC1A or PPARGC1B…
Nucleus, Chromosome, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
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