LYR motif-containing protein 4 (LYRM4) is a 91-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9HD34.
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The mean pLDDT of this model is 93.1 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 87% |
| 70 to 90 | Confident: backbone generally right | 4% |
| 50 to 70 | Low: treat with caution | 9% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Stabilizing factor, of the core iron-sulfur cluster (ISC) assembly complex, that regulates, in association with NDUFAB1, the stability and the cysteine desulfurase activity of NFS1 and participates in the [2Fe-2S] clusters assembly on the scaffolding protein ISCU (PubMed:17331979, PubMed:31664822). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by…
Homodimer (PubMed:29097656, PubMed:31101807). Component of the mitochondrial core iron-sulfur cluster (ISC) complex composed of NFS1, LYRM4, NDUFAB1, ISCU, FXN, and FDX2; this complex is a heterohexamer containing two copies of each monomer (Probable). Component of the cyteine desulfurase complex composed of NFS1, LYRM4 and NDUFAB1; this complex contributes to the stability and cysteine…
Mitochondrion, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6UXE | X-ray | 1.57 Å | B=1-91 |
| 6W1D | X-ray | 1.79 Å | B=1-91 |
| 6WIH | X-ray | 1.9 Å | B=1-91 |
| 6WI2 | X-ray | 1.95 Å | B=1-91 |
| 6ODD | X-ray | 2.0 Å | B=5-78 |
| 8TVT | X-ray | 2.0 Å | B=1-91 |
| 8RMC | EM | 2.26 Å | B/F=1-91 |
| 8RMF | EM | 2.33 Å | B/F=1-91 |
| 8RMG | EM | 2.46 Å | B/F=1-91 |
| 8PK8 | EM | 2.49 Å | B=1-91 |
| 8RME | EM | 2.49 Å | B/F=1-91 |
| 7RTK | X-ray | 2.5 Å | B=1-91 |
| 8RMD | EM | 2.52 Å | B/F=1-91 |
| 8PK9 | EM | 2.58 Å | B=1-91 |
| 5WGB | X-ray | 2.75 Å | B=1-91 |
| 8PKA | EM | 2.75 Å | B=1-91 |
| 5USR | X-ray | 3.09 Å | B/D/F/H=1-91 |
| 5WKP | X-ray | 3.15 Å | B/F=1-91 |
| 6NZU | EM | 3.2 Å | B/F=1-91 |
| 5WLW | X-ray | 3.32 Å | B/F=1-91 |
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