Q9JHF9: Lymphocyte antigen 96 (Ly96)

Lymphocyte antigen 96 (Ly96) is a 160-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9JHF9.

Gene
Ly96
Organism
Mus musculus
Length
160 residues
Mean pLDDT
86.8
Model
AF-Q9JHF9-F1 v6
Model created
1 Aug 2025
PDB structures
10

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Model confidence (pLDDT)

The mean pLDDT of this model is 86.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.

pLDDT bandMeaningShare of residues
Above 90Very high: backbone and side chains are usually accurate69%
70 to 90Confident: backbone generally right16%
50 to 70Low: treat with caution6%
Below 50Very low: often disordered regions8%

What pLDDT means and how to read it

Function

Binds bacterial lipopolysaccharide (LPS) (PubMed:22532668). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS (PubMed:10725698)

Subunit structure

Heterogeneous homomer formed from homodimers; disulfide-linked (By similarity). Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4 (PubMed:10725698, PubMed:20133493, PubMed:24380872). Binds to the extracellular domain of TLR4 (PubMed:10725698, PubMed:17803912, PubMed:20133493, PubMed:22532668, PubMed:24380872). Binds to the…

Subcellular location

Secreted, extracellular space, Secreted

Experimental structures in the PDB

Compare the prediction with experimentally determined structures of the same protein:

PDB IDMethodResolutionChains and residues
7MLMX-ray2.1 ÅC=19-160
3VQ2X-ray2.48 ÅC/D=17-160
5IJCX-ray2.57 ÅC/D=19-160
8WQTEM2.6 ÅC/D=19-160
8WRYEM2.6 ÅC/D=19-160
3VQ1X-ray2.7 ÅC/D=17-160
5IJDX-ray2.7 ÅC/D=19-160
2Z64X-ray2.84 ÅC=21-155
5IJBX-ray2.91 ÅC/D=19-160
8WSAEM3.1 ÅC/D=19-160

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