Carbohydrate-responsive element-binding protein (MLXIPL) is a 852-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9NP71.
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The mean pLDDT of this model is 53.8 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 15% |
| 70 to 90 | Confident: backbone generally right | 12% |
| 50 to 70 | Low: treat with caution | 13% |
| Below 50 | Very low: often disordered regions | 60% |
What pLDDT means and how to read it
Glucose-responsive transcription activator that regulates fatty acid synthesis and glycolysis. Key determinant of systemic insulin sensitivity and glucose homeostasis. Important for the expression of fatty acid synthetic enzymes, including PC/Pcx, APOC4/Acl, ACACA/Acc1 and FASN/Fas (By similarity). Important for glucose-induced expression of L-type pyruvate kinase/PKLR (By similarity). Binds to the canonical and non-canonical E box DNA sequences 5'-CACGTG-3' and 5'-CACGCG-3' (By similarity). May also act as a transcriptional repressor (By similarity)
Binds DNA as a heterodimer with MLX/TCFL4
Cytoplasm, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8BTQ | X-ray | 1.6 Å | B=117-135 |
| 8C1Y | X-ray | 1.8 Å | B=117-134 |
| 8BWE | X-ray | 2.0 Å | B=117-134 |
| 6YGJ | X-ray | 2.07 Å | B/I=117-137 |
| 8BWH | X-ray | 2.1 Å | B=117-134 |
| 6MJL | X-ray | 2.5 Å | A=168-176 |
| 9GCP | X-ray | 2.59 Å | B/D/F/H=117-136 |
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