Acetyl-coenzyme A synthetase 2-like, mitochondrial (ACSS1) is a 689-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9NUB1.
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The mean pLDDT of this model is 87.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 65% |
| 70 to 90 | Confident: backbone generally right | 23% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 8% |
What pLDDT means and how to read it
Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (PubMed:16788062). Acetate is the preferred substrate (PubMed:16788062). Can also utilize propionate with a much lower affinity (By similarity). Provides acetyl-CoA that is utilized mainly for oxidation under ketogenic conditions (By similarity). Involved in thermogenesis under ketogenic conditions, using acetate as a vital fuel when carbohydrate availability is insufficient (By similarity)
Interacts with SIRT3
Mitochondrion matrix
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3GLR | X-ray | 1.8 Å | B=638-649 |
| 4C78 | X-ray | 2.0 Å | C=638-647 |
| 4BVE | X-ray | 2.05 Å | B=638-647 |
| 3GLT | X-ray | 2.1 Å | B=638-649 |
| 3GLU | X-ray | 2.5 Å | B=638-649 |
| 4BVG | X-ray | 2.5 Å | B=638-647 |
| 5Y4H | X-ray | 2.6 Å | B=638-649 |
| 4BVF | X-ray | 2.7 Å | B=638-647 |
| 5YTK | X-ray | 2.7 Å | G/J/K/L=638-645 |
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