Kelch repeat and BTB domain-containing protein 4 (KBTBD4) is a 534-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9NVX7.
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The mean pLDDT of this model is 77.7 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 42% |
| 70 to 90 | Confident: backbone generally right | 32% |
| 50 to 70 | Low: treat with caution | 10% |
| Below 50 | Very low: often disordered regions | 17% |
What pLDDT means and how to read it
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex which targets CoREST corepressor complex components RCOR1, KDM1A/LSD1 and HDAC2 for proteasomal degradation (PubMed:33417871). RCOR1 is likely to be the primary target while degradation of KDM1A and HDAC2 is likely due to their association with RCOR1 (PubMed:33417871). Also targets RCOR3, MIER2 and MIER3 for proteasomal degradation as well as associated proteins ZNF217 and RREB1 (PubMed:36997086). Degradation is dependent on the presence of an ELM2 domain in the target proteins (PubMed:36997086)
Component of the BCR(KBTBD4) E3 ubiquitin ligase complex, at least composed of CUL3, KBTBD4 and RBX1
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9GGM | EM | 2.71 Å | A/C=17-534 |
| 9DTQ | EM | 2.87 Å | B/E=17-534 |
| 9GGN | EM | 2.9 Å | A/C=17-534 |
| 9GGL | EM | 3.13 Å | A/C=17-534 |
| 8VPQ | EM | 3.3 Å | A/B=1-534 |
| 9I2C | EM | 3.3 Å | A/C=17-534 |
| 8VRT | EM | 3.42 Å | A/B=17-534 |
| 8VOJ | EM | 3.77 Å | A/B=1-534 |
| 9DTG | EM | 3.83 Å | A/B=1-534 |
| 2EQX | NMR | A=158-255 |
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