Dipeptidyl peptidase 3 (DPP3) is a 737-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9NY33.
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The mean pLDDT of this model is 95.3 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 92% |
| 70 to 90 | Confident: backbone generally right | 7% |
| 50 to 70 | Low: treat with caution | 1% |
| Below 50 | Very low: often disordered regions | 1% |
What pLDDT means and how to read it
Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin (PubMed:1515063, PubMed:3233187). Also cleaves Arg-Arg-beta-naphthylamide (in vitro) (PubMed:11209758, PubMed:3233187, PubMed:9425109)
Cytoplasm, cytosol
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5E33 | X-ray | 1.84 Å | A=1-726 |
| 3FVY | X-ray | 1.9 Å | A=1-726 |
| 5E3A | X-ray | 2.05 Å | A=1-726 |
| 5EHH | X-ray | 2.38 Å | A=1-726 |
| 3T6B | X-ray | 2.4 Å | A/B=1-726 |
| 5E2Q | X-ray | 2.4 Å | A=1-726 |
| 7OUP | X-ray | 2.65 Å | A=1-737 |
| 5EGY | X-ray | 2.74 Å | A=1-726 |
| 5E3C | X-ray | 2.77 Å | A=1-726 |
| 3T6J | X-ray | 2.98 Å | A=1-726 |
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