Sentrin-specific protease 1 (SENP1) is a 644-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9P0U3.
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The mean pLDDT of this model is 60.4 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 33% |
| 70 to 90 | Confident: backbone generally right | 8% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 53% |
What pLDDT means and how to read it
Protease that catalyzes two essential functions in the SUMO pathway (PubMed:10652325, PubMed:15199155, PubMed:15487983, PubMed:16253240, PubMed:16553580, PubMed:21829689, PubMed:21965678, PubMed:23160374, PubMed:24943844, PubMed:25406032, PubMed:29506078, PubMed:34048572, PubMed:37257451). The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins (PubMed:15487983). The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the…
Interacts with RBM33; promoting ALKBH5 desumoylation and subsequent activation
Nucleus, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2XPH | X-ray | 2.4 Å | A/B=415-644 |
| 2CKG | X-ray | 2.45 Å | A/B=419-644 |
| 2IYC | X-ray | 2.45 Å | A/B=419-644 |
| 2XRE | X-ray | 2.45 Å | A/B=415-644 |
| 2IY1 | X-ray | 2.46 Å | A/C=419-644 |
| 6NNQ | X-ray | 2.62 Å | A=421-644 |
| 2IY0 | X-ray | 2.77 Å | A=419-644 |
| 2G4D | X-ray | 2.8 Å | A/C=440-644 |
| 2CKH | X-ray | 3.2 Å | A=419-644 |
| 2IYD | X-ray | 3.2 Å | A=419-644 |
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