AMSH-like protease sst2 (sst2) is a 435-residue protein from Schizosaccharomyces pombe (strain 972 / ATCC 24843). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9P371.
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The mean pLDDT of this model is 77.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 57% |
| 70 to 90 | Confident: backbone generally right | 17% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 22% |
What pLDDT means and how to read it
Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Plays a role in the multivesicular body (MVB) sorting pathway. Required for ubiquitin-dependent sorting of proteins into the endosome and subsequent trafficking to the vacuole. May regulate MVB sorting through deubiquitination of ubiquitinated ESCRT proteins
Cytoplasm, Endosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4JXE | X-ray | 1.45 Å | A/B=245-435 |
| 4K1R | X-ray | 1.63 Å | A/C=245-435 |
| 4ZD4 | X-ray | 1.63 Å | A/B=245-435 |
| 4MS7 | X-ray | 1.67 Å | A/B=245-435 |
| 4ZFR | X-ray | 1.72 Å | A=245-435 |
| 4MSM | X-ray | 1.74 Å | A/C=245-435 |
| 4MSJ | X-ray | 1.8 Å | A/B/C=245-435 |
| 4MSD | X-ray | 1.9 Å | A/B=245-435 |
| 4MSQ | X-ray | 1.95 Å | A/C=245-435 |
| 4PQT | X-ray | 2.05 Å | A=245-435 |
| 4ZD5 | X-ray | 2.07 Å | A/B=245-435 |
| 4NQL | X-ray | 2.3 Å | A=221-435 |
| 4ZFT | X-ray | 2.3 Å | A/C=245-435 |
| 7LM3 | X-ray | 2.7 Å | A/B=245-435 |
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