Toll-like receptor 4 (Tlr4) is a 835-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9QUK6.
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The mean pLDDT of this model is 90.1 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 75% |
| 70 to 90 | Confident: backbone generally right | 17% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 6% |
What pLDDT means and how to read it
Transmembrane receptor that functions as a pattern recognition receptor recognizing pathogen- and damage-associated molecular patterns (PAMPs and DAMPs) to induce innate immune responses via downstream signaling pathways (PubMed:20133493, PubMed:9851930, PubMed:9989976). At the plasma membrane, cooperates with LY96 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:20133493, PubMed:9851930, PubMed:9989976). Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni(2+). Mechanistically, acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response…
Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4 (PubMed:24380872). Binding to bacterial LPS leads to homodimerization (PubMed:20133493, PubMed:22532668, PubMed:24380872). Interacts with LY96 via the extracellular domain (PubMed:17803912, PubMed:22532668). Interacts with MYD88 (via the TIR domain). Interacts with TICAM2 and TIRAP…
Cell membrane, Early endosome, Cell projection, ruffle
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7MLM | X-ray | 2.1 Å | A=26-544 |
| 3VQ2 | X-ray | 2.48 Å | A/B=22-627 |
| 5IJC | X-ray | 2.57 Å | A/B=26-544 |
| 8WQT | EM | 2.6 Å | A/B=26-629 |
| 8WRY | EM | 2.6 Å | A/B=26-629 |
| 3VQ1 | X-ray | 2.7 Å | A/B=22-627 |
| 5IJD | X-ray | 2.7 Å | A/B=26-544 |
| 2Z64 | X-ray | 2.84 Å | A=27-625 |
| 5IJB | X-ray | 2.91 Å | A/B=26-544 |
| 8WSA | EM | 3.1 Å | A/B=26-629 |
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