Cardiotrophin-like cytokine factor 1 (CLCF1) is a 225-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9UBD9.
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The mean pLDDT of this model is 81.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 57% |
| 70 to 90 | Confident: backbone generally right | 13% |
| 50 to 70 | Low: treat with caution | 19% |
| Below 50 | Very low: often disordered regions | 11% |
What pLDDT means and how to read it
Functions as a cytokine, either alone or by forming a stable complex with soluble CRLF1 or CNTFR (PubMed:10448081, PubMed:10500198, PubMed:10966616, PubMed:11285233, PubMed:11294841). Binds to CNTFR complex (CNTFR, IL6ST/gp130, LIFR) or can signal via trans-signaling using soluble CNTFR subunits (PubMed:10966616, PubMed:11285233, PubMed:11294841). Mechanistically, ligand binding to CNTFR, induces dimerization of the IL6ST/gp130 and LIFR, which activates JAK tyrosine kinases (JAK1 or JAK2 and to lesser extent TYK2) bound to their intracellular domains (PubMed:11294841, PubMed:16782820). These kinases subsequently phosphorylate IL6ST/gp130 and LIFR (PubMed:11294841). The tyrosine…
Homodimer (PubMed:36930708). Forms a heterotetrameric complex with CRLF1/CLF-1; this complex is a ligand of the ciliary neurotrophic factor (CNTF) receptor complex through CLCF1 and CNTFR binding (PubMed:10966616, PubMed:26858303, PubMed:36930708). The CRLF1-CLCF1 heterodimer interacts with SORL1 (via Vps10p domain); within this complex, the interaction is mediated predominantly by the CRLF1…
Secreted
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