SUMO-activating enzyme subunit 2 (UBA2) is a 640-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9UBT2.
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The mean pLDDT of this model is 85.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 66% |
| 70 to 90 | Confident: backbone generally right | 18% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 12% |
What pLDDT means and how to read it
The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2
Heterodimer of SAE1 and UBA2/SAE2. The heterodimer corresponds to the two domains that are encoded on a single polypeptide chain in ubiquitin-activating enzyme E1. Interacts with UBE2I
Cytoplasm, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9QN5 | X-ray | 1.97 Å | B/D=1-640 |
| 6XOG | X-ray | 1.98 Å | B=1-640 |
| 6XOI | X-ray | 2.0 Å | B=1-640 |
| 5FQ2 | X-ray | 2.2 Å | B=446-547 |
| 6XOH | X-ray | 2.23 Å | B=1-640 |
| 1Y8Q | X-ray | 2.25 Å | B/D=1-640 |
| 3KYC | X-ray | 2.45 Å | B=1-640 |
| 6CWY | X-ray | 2.46 Å | D=1-640 |
| 4W5V | X-ray | 2.5 Å | B=445-561 |
| 9IF6 | X-ray | 2.51 Å | B/D=1-640 |
| 3KYD | X-ray | 2.61 Å | B=1-549 |
| 9DRJ | EM | 2.7 Å | B=1-548 |
| 1Y8R | X-ray | 2.75 Å | B/E=1-640 |
| 6CWZ | X-ray | 3.1 Å | D=1-640 |
| 9DQB | EM | 3.6 Å | B=1-548 |
| 2PX9 | NMR | A=166-382 |
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