MAGE-like protein 2 (MAGEL2) is a 1249-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9UJ55.
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The mean pLDDT of this model is 43.5 (very low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 9% |
| 70 to 90 | Confident: backbone generally right | 6% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 83% |
What pLDDT means and how to read it
Probably enhances ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases, possibly through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Acts as a regulator of retrograde transport via its interaction with VPS35. Recruited to retromer-containing endosomes and promotes the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1 together with TRIM27, leading to promote endosomal F-actin assembly (PubMed:23452853). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Significantly promotes the cytoplasmic accumulation of CLOCK…
Part of a complex consisting of MAGEL2, TRIM27 and USP7; directly interacts with USP7 (PubMed:26365382). Interacts with TRIM27 (PubMed:23452853). Interacts with VPS35; leading to recruitment at retromer-containing endosomes (PubMed:23452853). Interacts with BMAL1 and PER2 (By similarity)
Early endosome, Cytoplasm, Nucleus
UniProt lists no experimental PDB structure for this protein, so the AlphaFold prediction is the main 3D model available.
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