NTF2-related export protein 1 (NXT1) is a 140-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9UKK6.
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The mean pLDDT of this model is 94.1 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 87% |
| 70 to 90 | Confident: backbone generally right | 9% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 1% |
What pLDDT means and how to read it
Stimulator of protein export for NES-containing proteins (PubMed:10567585). Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA (PubMed:10848583). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 (PubMed:11259602, PubMed:19165146)
Heterodimer with NXF1 (PubMed:11583626). Forms a complex with RANGAP1, RANBP2/NUP358 and NXF1 (PubMed:14729961). Interacts (via NTF2 domain) with NXF1 (PubMed:11583626). Stabilizes the NTF2 domain of NXF1 by heterodimerization (PubMed:11583626). The formation of NXF1-NXT1 heterodimers is required for the NXF1-mediated nuclear mRNA export (PubMed:11583626). Preferentially binds Ran-GTP…
Nucleus, Nucleus speckle, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9I8A | X-ray | 1.5 Å | A=3-140 |
| 1JKG | X-ray | 1.9 Å | A=1-140 |
| 1JN5 | X-ray | 2.8 Å | A=1-140 |
| 4WYK | X-ray | 3.4 Å | B/D=2-140 |
| 6E5U | X-ray | 3.8 Å | B/D/F/H=1-140 |
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