Zinc finger protein Helios (IKZF2) is a 526-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9UKS7.
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The mean pLDDT of this model is 52.4 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 0% |
| 70 to 90 | Confident: backbone generally right | 33% |
| 50 to 70 | Low: treat with caution | 13% |
| Below 50 | Very low: often disordered regions | 53% |
What pLDDT means and how to read it
Transcription factor, which stabilizes the noninflammatory phenotype of regulatory T cells (Tregs) (By similarity). May possibly act via STAT5-mediated signaling (By similarity). Binds IL2 promoter and represses its transcription, possibly by epigenetic silencing, inducing deacetylation of core histones in the IL2 promoter (PubMed:37316189). In Tregs, required for FOXP3 recruitment to the IL2 promoter (By similarity). Required for outer hair cells maturation and, consequently, for hearing (By similarity)
Can form homodimers (PubMed:34826259). Interacts with IKZF1 and IKZF3 (PubMed:34826259, PubMed:34826260). Interacts with IKZF4 (PubMed:10978333, PubMed:34826259). Interacts with IKZF5 (PubMed:10978333). Interacts with HDAC1 (PubMed:34826259)
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9OHQ | X-ray | 1.6 Å | B/D/F/H=136-164 |
| 9DOM | X-ray | 1.69 Å | B/D/F/H=136-164 |
| 9O91 | X-ray | 1.86 Å | B/D/F/H=136-164 |
| 9OHR | X-ray | 2.34 Å | B/D/F/H=136-164 |
| 9Q22 | X-ray | 3.41 Å | C=135-163 |
| 8DEY | X-ray | 3.7 Å | C/F=137-192 |
| 7LPS | X-ray | 3.78 Å | C/F/I/L=136-164 |
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