Ras GTPase-activating protein-binding protein 2 (G3BP2) is a 482-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9UN86.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 65.6 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 28% |
| 70 to 90 | Confident: backbone generally right | 16% |
| 50 to 70 | Low: treat with caution | 11% |
| Below 50 | Very low: often disordered regions | 45% |
What pLDDT means and how to read it
Scaffold protein that plays an essential role in cytoplasmic stress granule formation which acts as a platform for antiviral signaling (PubMed:23279204, PubMed:32302570, PubMed:32302571, PubMed:32302572). Plays an essential role in stress granule formation (PubMed:27022092, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:35977029). Stress granules are membraneless compartments that store mRNAs and proteins, such as stalled translation pre-initiation complexes, in response to stress (PubMed:32302570, PubMed:32302571, PubMed:32302572). Promotes formation of stress granules phase-separated membraneless compartment by undergoing liquid-liquid phase separation (LLPS) upon unfolded…
Forms homooligomers (PubMed:23279204). Forms heterodimers with G3BP1 (PubMed:23279204). Interacts with NFKBIA (via N-terminus) (PubMed:10969074). Interacts (via NTF2 domain) with USP10; inhibiting stress granule formation (PubMed:23279204, PubMed:27022092, PubMed:31981475). Interacts (via NTF2 domain) with CAPRIN1; promoting stress granule formation (PubMed:27022092). Associates (via RG-rich…
Cytoplasm, Cytoplasm, Stress granule
Compare the prediction with experimentally determined structures of the same protein:
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.