NAD-dependent protein deacetylase (cobB) is a 246-residue protein from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9WYW0.
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The mean pLDDT of this model is 95.7 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 91% |
| 70 to 90 | Confident: backbone generally right | 9% |
| 50 to 70 | Low: treat with caution | 1% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. Also has depropionylation activity in vitro. Also able to ADP-ribosylate peptide substrates with Arg or Lys in the +2 position. The role of this function in vivo is not clear
Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1YC5 | X-ray | 1.4 Å | A=1-246 |
| 3JR3 | X-ray | 1.5 Å | A=1-246 |
| 2H2G | X-ray | 1.63 Å | A=1-246 |
| 2H2D | X-ray | 1.7 Å | A=1-246 |
| 2H2I | X-ray | 1.8 Å | A=1-246 |
| 3PDH | X-ray | 1.8 Å | A=1-246 |
| 2H59 | X-ray | 1.9 Å | A/B=1-246 |
| 3D4B | X-ray | 1.9 Å | A=1-246 |
| 4BUZ | X-ray | 1.9 Å | A=1-246 |
| 2H4H | X-ray | 1.99 Å | A=1-246 |
| 2H4F | X-ray | 2.0 Å | A=1-246 |
| 2H4J | X-ray | 2.1 Å | A=1-246 |
| 2H2F | X-ray | 2.2 Å | A=1-246 |
| 2H2H | X-ray | 2.2 Å | A=1-246 |
| 3D81 | X-ray | 2.5 Å | A=1-246 |
| 4BV2 | X-ray | 3.3 Å | A/B=1-246 |
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