Mitogen-activated protein kinase kinase kinase 2 (MAP3K2) is a 619-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9Y2U5.
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The mean pLDDT of this model is 67.7 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 37% |
| 70 to 90 | Confident: backbone generally right | 18% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 40% |
What pLDDT means and how to read it
Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics
Interacts with PKN2; the interaction activates PKN2 kinase activity in a MAP3K2-independent kinase activity (By similarity). Self-associates. Binds both upstream activators and downstream substrates in multimolecular complexes. Interacts (via the kinase catalytic domain) with STK38. Interacts with XIAP/BIRC4
Cytoplasm, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6LDW | X-ray | 1.6 Å | C/D=252-265 |
| 5HQ8 | X-ray | 1.72 Å | I/J=250-264 |
| 2NPT | X-ray | 1.75 Å | B/D=26-123 |
| 6LDY | X-ray | 1.77 Å | C/M=252-265 |
| 6LDX | X-ray | 1.8 Å | B=252-265 |
| 6LDV | X-ray | 1.9 Å | P=252-265 |
| 9P6A | X-ray | 2.4 Å | A/B=325-619 |
| 5EX0 | X-ray | 2.7 Å | D=256-265 |
| 2CU1 | NMR | A=43-132 |
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