Thioredoxin-related transmembrane protein 2 (TMX2) is a 296-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9Y320.
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The mean pLDDT of this model is 85.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 67% |
| 70 to 90 | Confident: backbone generally right | 20% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 8% |
What pLDDT means and how to read it
Endoplasmic reticulum and mitochondria-associated protein that probably functions as a regulator of cellular redox state and thereby regulates protein post-translational modification, protein folding and mitochondrial activity. Indirectly regulates neuronal proliferation, migration, and organization in the developing brain
Monomer (PubMed:31735293). Homodimer; disulfide-linked (PubMed:31735293). Occurs in both reduced and oxidized monomeric form (PubMed:31735293). Oxidative conditions increase homodimerization (PubMed:31735293). Interacts with CANX (PubMed:31735293). Interacts with ATP2A2 (PubMed:31735293)
Endoplasmic reticulum membrane, Mitochondrion membrane
Compare the prediction with experimentally determined structures of the same protein:
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