WD repeat domain phosphoinositide-interacting protein 2 (WIPI2) is a 454-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9Y4P8.
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The mean pLDDT of this model is 76.0 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 60% |
| 70 to 90 | Confident: backbone generally right | 7% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 27% |
What pLDDT means and how to read it
Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:20505359, PubMed:28561066). Involved in an early step of the formation of preautophagosomal structures (PubMed:20505359, PubMed:28561066). Binds and is activated by phosphatidylinositol 3-phosphate (PtdIns3P) forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases (PubMed:28561066). Mediates ER-isolation membranes contacts by interacting with the ULK1:RB1CC1 complex and PtdIns3P (PubMed:28890335). Once activated, WIPI2 recruits at…
Interacts with TECPR1 (PubMed:21575909). Interacts with ATG16L1 (PubMed:24954904, PubMed:28561066). Interacts with ATG5 (PubMed:24954904). Interacts with WIPI1 (PubMed:28561066). Interacts with WDR45 (PubMed:28561066). May interact with NUDC (PubMed:28561066). Interacts with ULK1 and RB1CC1 (PubMed:28890335). Interacts with UBAC2; interaction increases upon the activation of starvation-induced…
Preautophagosomal structure membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7F69 | X-ray | 1.5 Å | A=13-379 |
| 7XFR | X-ray | 1.76 Å | A/C=13-380 |
| 7MU2 | X-ray | 1.85 Å | A/C=12-381 |
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