DNA-directed RNA polymerase III subunit RPC8 (POLR3H) is a 204-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9Y535.
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The mean pLDDT of this model is 88.0 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 76% |
| 70 to 90 | Confident: backbone generally right | 14% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 7% |
What pLDDT means and how to read it
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:20413673, PubMed:33558764, PubMed:34675218). Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. With CRCP/RPC9 forms a mobile stalk that protrudes from Pol III core and functions primarily in transcription initiation (By similarity) (PubMed:33558764, PubMed:34675218). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in…
Component of the RNA polymerase III complex consisting of 17 subunits: a ten-subunit horseshoe-shaped catalytic core composed of POLR3A/RPC1, POLR3B/RPC2, POLR1C/RPAC1, POLR1D/RPAC2, POLR3K/RPC10, POLR2E/RPABC1, POLR2F/RPABC2, POLR2H/RPABC3, POLR2K/RPABC4 and POLR2L/RPABC5; a mobile stalk composed of two subunits POLR3H/RPC8 and CRCP/RPC9, protruding from the core and functioning primarily in…
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7AE1 | EM | 2.8 Å | G=1-204 |
| 9K39 | EM | 2.8 Å | G=1-204 |
| 7D58 | EM | 2.9 Å | G=1-204 |
| 9K36 | EM | 2.9 Å | G=1-204 |
| 9K2G | EM | 3.0 Å | G=1-204 |
| 9K3U | EM | 3.0 Å | G=1-204 |
| 7AE3 | EM | 3.1 Å | G=1-204 |
| 7D59 | EM | 3.1 Å | G=1-204 |
| 9K38 | EM | 3.1 Å | G=1-204 |
| 9FSO | EM | 3.28 Å | H=1-204 |
| 7A6H | EM | 3.3 Å | G=1-204 |
| 9LXN | EM | 3.3 Å | G=1-204 |
| 7DU2 | EM | 3.35 Å | G=1-204 |
| 9FSP | EM | 3.39 Å | H=1-204 |
| 7AEA | EM | 3.4 Å | G=1-204 |
| 8IUH | EM | 3.4 Å | G=1-204 |
| 7DN3 | EM | 3.5 Å | G=1-204 |
| 9K3V | EM | 3.5 Å | G=1-204 |
| 9LKT | EM | 3.5 Å | G=1-204 |
| 9FSQ | EM | 3.51 Å | H=1-204 |
Showing 20 of 29 experimental structures (best resolution first).
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