NEDD8 ultimate buster 1 (NUB1) is a 615-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9Y5A7.
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The mean pLDDT of this model is 83.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 48% |
| 70 to 90 | Confident: backbone generally right | 37% |
| 50 to 70 | Low: treat with caution | 9% |
| Below 50 | Very low: often disordered regions | 7% |
What pLDDT means and how to read it
Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation. Isoform 1 promotes the degradation of NEDD8 more efficiently than isoform 2
Directly interacts with NEDD8 and PSMD4/S5a, a member of the regulatory subunit of the 26S proteasome. Isoform 1 binds to NEDD8 more efficiently than isoform 2. Interacts with AIPL1. The interaction with UBD via UBA domains facilitates the linking of UBD-conjugated target protein to the proteasome complex and accelerates UBD degradation and that of its conjugates
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8USD | EM | 2.7 Å | g=1-254 |
| 9E8I | EM | 2.87 Å | g=1-615 |
| 9E8H | EM | 2.9 Å | g=1-615 |
| 9E8G | EM | 3.01 Å | g=1-615 |
| 8USC | EM | 3.1 Å | g=1-615 |
| 9E8J | EM | 3.47 Å | g=1-615 |
| 9E8L | EM | 3.59 Å | g=1-615 |
| 9E8N | EM | 3.62 Å | g=1-615 |
| 1WJU | NMR | A=75-161 |
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