Histamine H3 receptor (HRH3) is a 445-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9Y5N1.
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The mean pLDDT of this model is 75.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 39% |
| 70 to 90 | Confident: backbone generally right | 31% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 24% |
What pLDDT means and how to read it
The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 neither modified adenylate cyclase activity nor induced intracellular calcium mobilization
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7F61 | X-ray | 2.6 Å | A=27-433 |
| 8YN5 | EM | 2.7 Å | R=1-445 |
| 8YUU | EM | 2.7 Å | R=1-445 |
| 8YN6 | EM | 2.77 Å | R=1-445 |
| 8YN7 | EM | 2.77 Å | R=1-445 |
| 8YN8 | EM | 2.77 Å | R=1-445 |
| 8YUV | EM | 3.0 Å | R=1-445 |
| 9JEQ | EM | 3.05 Å | R=1-445 |
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