Lymphocyte antigen 96 (LY96) is a 160-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9Y6Y9.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 87.7 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 67% |
| 70 to 90 | Confident: backbone generally right | 18% |
| 50 to 70 | Low: treat with caution | 15% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Binds bacterial lipopolysaccharide (LPS) (PubMed:17569869, PubMed:17803912). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria (PubMed:11160242, PubMed:11593030). Enhances TLR4-dependent activation of NF-kappa-B (PubMed:10359581). Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS (PubMed:10359581)
Heterogeneous homomer formed from homodimers; disulfide-linked (PubMed:11593030, PubMed:12642668). Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4 (PubMed:11274165). Binds to the extracellular domains of TLR2 and TLR4 (PubMed:10359581, PubMed:11593030, PubMed:17803912). Ligand binding induces interaction with TLR4 and…
Secreted, extracellular space, Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2E56 | X-ray | 2.0 Å | A=17-160 |
| 2E59 | X-ray | 2.21 Å | A=17-160 |
| 8WO1 | EM | 2.24 Å | C/D=19-160 |
| 4G8A | X-ray | 2.4 Å | C/D=17-160 |
| 2Z65 | X-ray | 2.7 Å | C/D=19-158 |
| 9J03 | EM | 2.7 Å | C/D=19-160 |
| 8WTA | EM | 2.9 Å | C/D=19-160 |
| 3FXI | X-ray | 3.1 Å | C/D=19-160 |
| 3ULA | X-ray | 3.6 Å | B/D=19-158 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.