IgG H chain is a 275-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Jun 2022. UniProt accession: S6B2B6.
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The mean pLDDT of this model is 80.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 56% |
| 70 to 90 | Confident: backbone generally right | 18% |
| 50 to 70 | Low: treat with caution | 10% |
| Below 50 | Very low: often disordered regions | 16% |
What pLDDT means and how to read it
Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked
Cell membrane, Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5W6C | X-ray | 1.63 Å | H=20-250 |
| 6UDJ | EM | 2.5 Å | A/K/Q=20-119, A/K/Q=121-251 |
| 5W6G | X-ray | 2.79 Å | H=20-250 |
| 6UDK | EM | 3.9 Å | A/F/O=20-119, A/F/O=121-251 |
| 5W1K | X-ray | 3.99 Å | D/I/O/Q=21-245 |
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