IgG H chain is a 275-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Jun 2022. UniProt accession: S6C4S0.
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The mean pLDDT of this model is 82.2 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 57% |
| 70 to 90 | Confident: backbone generally right | 22% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 14% |
What pLDDT means and how to read it
Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked
Cell membrane, Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5W08 | X-ray | 2.6 Å | G/I/K/M/O/Q=20-247 |
| 4NM4 | X-ray | 2.65 Å | H/I=20-245 |
| 4O58 | X-ray | 2.75 Å | H=20-245 |
| 5UGY | X-ray | 2.8 Å | H/I/J=20-243 |
| 6CBJ | X-ray | 2.85 Å | H=20-247 |
| 6UTA | X-ray | 3.1 Å | A/H=20-249 |
| 6MYY | EM | 3.8 Å | D/G/H=20-248 |
| 6UDK | EM | 3.9 Å | D/H/M=1-45, D/H/M=48-249 |
| 4NM8 | X-ray | 4.0 Å | H/I/J=20-245 |
| 6MZJ | EM | 4.8 Å | D/H=20-248 |
| 4O5I | X-ray | 6.5 Å | M/O/Q/S/U/W=20-245 |
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