PCSK9 in complex with cyclic peptide 21. Determined by X-ray diffraction at 1.83 Å resolution. Released 3 Jun 2026.
Explore 10SB in 3D Show helices and sheets RCSB PDB PDBe
10SB contains 17 α-helices and 27 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 63-65 | 3 | 1 |
| α-helix | 70-72 | 3 | |
| β-strand | 73-82 | 10 | 1 |
| α-helix | 83 | 1 | |
| α-helix | 88-104 | 17 | |
| β-strand | 110-115 | 6 | 1 |
| β-strand | 121-125 | 5 | 1 |
| α-helix | 128-130 | 3 | |
| α-helix | 131-134 | 4 | |
| β-strand | 140-147 | 8 | 1 |
| β-strand | 148-151 | 4 | 2 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 156-160 | 5 | |
| β-strand | 181-186 | 6 | 3 |
| β-strand | 200-206 | 7 | 3 |
| α-helix | 209-211 | 3 | |
| α-helix | 220-235 | 16 | |
| β-strand | 246-251 | 6 | 3 |
| β-strand | 258-260 | 3 | 2 |
| α-helix | 261-277 | 17 | |
| β-strand | 283-287 | 5 | 3 |
| β-strand | 289-292 | 4 | 2 |
| α-helix | 295-306 | 12 | |
| β-strand | 310-314 | 5 | 3 |
| β-strand | 318 | 1 | 4 |
| β-strand | 321 | 1 | 5 |
| α-helix | 322-324 | 3 | |
| β-strand | 325-326 | 2 | 2 |
| β-strand | 334-339 | 6 | 3 |
| α-helix | 344 | 1 | |
| β-strand | 345 | 1 | 3 |
| α-helix | 346 | 1 | |
| β-strand | 347-348 | 2 | 4 |
| β-strand | 351-352 | 2 | 4 |
| β-strand | 355 | 1 | 5 |
| β-strand | 361-364 | 4 | 3 |
| β-strand | 368-371 | 4 | 6 |
| β-strand | 379-382 | 4 | 6 |
| α-helix | 385-402 | 18 | |
| α-helix | 408-418 | 11 | |
| β-strand | 420-421 | 2 | 3 |
| α-helix | 426-428 | 3 | |
| α-helix | 431-433 | 3 | |
| β-strand | 440-441 | 2 | 3 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 3-4 | 2 | 6 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Propeptide of Proprotein convertase subtilisin/kexin type 9 | A | protein | 122 | Homo sapiens | Q8NBP7 (AlphaFold model) |
| Proprotein convertase subtilisin/kexin type 9 | B | protein | 308 | Homo sapiens | Q8NBP7 (AlphaFold model) |
| Cyclic peptide 21 | D | protein | 9 | synthetic construct |
>10SB_1 Propeptide of Proprotein convertase subtilisin/kexin type 9 (chains A) QEDEDGDYEELVLALRSEEDGLAEAPEHGTTATFHRCAKDPWRLPGTYVVVLKEETHLSQ SERTARRLQAQAARRGYLTKILHVFHGLLPGFLVKMSGDLLELALKLPHVDYIEEDSSVF AQ
>10SB_2 Proprotein convertase subtilisin/kexin type 9 (chains B) SIPWNLERITPPRYRADEYQPPDGGSLVEVYLLDTSIQSDHREIEGRVMVTDFENVPEED GTRFHRQASKCDSHGTHLAGVVSGRDAGVAKGASMRSLRVLNCQGKGTVSGTLIGLEFIR KSQLVQPVGPLVVLLPLAGGYSRVLNAACQRLARAGVVLVTAAGNFRDDACLYSPASAPE VITVGATNAQDQPVTLGTLGTNFGRCVDLFAPGEDIIGASSDCSTCFVSQSGTSQAAAHV AGIAAMMLSAEPELTLAELRQRLIHFSAKDVINEAWFPEDQRVLTPNLVAALPPSTHGAG NSHHHHHH
>10SB_3 Cyclic peptide 21 (chains D) XAXXWPTYX
| ID | Name | Formula | Copies |
|---|---|---|---|
| A1C8P | N-{[4-(2-aminoethyl)phenyl]methyl}hexan-1-amine | C15 H26 N2 | 1 |
| GOA | Glycolic acid | C2 H4 O3 | 1 |
Water and common crystallization additives (GOL) are not listed.
Discovery Process of Enlicitide, a Highly Engineered Macrocyclic Peptide Therapeutic, through Issue-Driven Fragment-Based Synthetic Assembly and SAR. Josien, H., Nair, A.G., Ding, F.X. et al. J Med Chem (2026) 69:13473-13491. DOI 10.1021/acs.jmedchem.6c00463 · PubMed
Other PDB entries of the same protein (UniProt Q8NBP7 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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