10SM: Importin-9

Importin-9 bound to ETS homologous factor (EHF). Determined by electron microscopy at 3.5 Å resolution. Released 27 May 2026.

Method
Electron microscopy
Resolution
3.5 Å
Organism
Homo sapiens
Chains
2
Atoms
8,084
Mol. weight
151 kDa
Released
27 May 2026

Explore 10SM in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

10SM contains 70 α-helices and 8 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 5 helices, 4 β-strands

ElementResiduesLengthSheet
α-helix209-21810
α-helix220-2223
β-strand227-23151
β-strand236-23941
α-helix242-25312
α-helix260-2689
α-helix269-2735
β-strand276-27831
β-strand285-28841
Chain D: 65 helices, 4 β-strands
ElementResiduesLengthSheet
α-helix24-3310
α-helix37-5115
α-helix54-6310
α-helix71-8717
α-helix103-11210
α-helix115-1184
α-helix122-15736
α-helix159-17315
α-helix182-19817
α-helix205-22319
α-helix228-2369
α-helix238-25316
α-helix2551
α-helix262-27615
α-helix280-2845
α-helix287-30519
α-helix306-3105
α-helix328-34518
α-helix350-36718
α-helix370-3712
α-helix372-3809
α-helix382-3898
α-helix398-41013
α-helix414-43724
α-helix441-4433
α-helix444-45613
α-helix458-46710
α-helix474-4774
α-helix478-4825
α-helix483-4875
α-helix492-50312
α-helix506-5083
α-helix511-52414
α-helix531-55121
α-helix554-5563
α-helix558-5603
α-helix561-57212
α-helix578-59114
α-helix595-61521
α-helix620-63415
α-helix637-65620
α-helix659-6613
α-helix666-67914
α-helix6821
α-helix685-6862
α-helix687-6882
α-helix689-6935
α-helix694-70310
α-helix707-72216
α-helix725-7306
β-strand73212
β-strand73812
α-helix739-75012
α-helix757-7604
α-helix763-77412
α-helix779-7813
α-helix782-79514
α-helix799-81315
α-helix817-82610
α-helix835-84713
α-helix853-87321
α-helix876-8794
β-strand882-88433
β-strand910-91233
α-helix913-93321
α-helix998-10014
α-helix1004-101613
α-helix1021-10277
α-helix1030-103910

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
ETS homologous factorAprotein300Homo sapiensQ9NZC4 (AlphaFold model)
Importin-9Dprotein1041Homo sapiensQ96P70 (AlphaFold model)
Sequence of entity 1 (A), FASTA
>10SM_1 ETS homologous factor (chains A)
MILEGGGVMNLNPGNNLLHQPPAWTDSYSTCNVSSGFFGGQWHEIHPQYWTKYQVWEWLQ
HLLDTNQLDANCIPFQEFDINGEHLCSMSLQEFTRAAGTAGQLLYSNLQHLKWNGQCSSD
LFQSTHNVIVKTEQTEPSIMNTWKDENYLYDTNYGSTVDLLDSKTFCRAQISMTTTSHLP
VAESPDMKKEQDPPAKCHTKKHNPRGTHLWEFIRDILLNPDKNPGLIKWEDRSEGVFRFL
KSEAVAQLWGKKKNNSSMTYEKLSRAMRYYYKREILERVDGRRLVYKFGKNARGWRENEN
Sequence of entity 2 (D), FASTA
>10SM_2 Importin-9 (chains D)
MAAAAAAGAASGLPGPVAQGLKEALVDTLTGILSPVQEVRAAAEEQIKVLEVTEEFGVHL
AELTVDPQGALAIRQLASVILKQYVETHWCAQSEKFRPPETTERAKIVIRELLPNGLRES
ISKVRSSVAYAVSAIAHWDWPEAWPQLFNLLMEMLVSGDLNAVHGAMRVLTEFTREVTDT
QMPLVAPVILPEMYKIFTMAEVYGIRTRSRAVEIFTTCAHMICNMEELEKGAAKVLIFPV
VQQFTEAFVQALQIPDGPTSDSGFKMEVLKAVTALVKNFPKHMVSSMQQILPIVWNTLTE
SAAFYVRTEVNYTEEVEDPVDSDGEVLGFENLVFSIFEFVHALLENSKFKSTVKKALPEL
IYYIILYMQITEEQIKVWTANPQQFVEDEDDDTFSYTVRIAAQDLLLAVATDFQNESAAA
LAAAATRHLQEAEQTKNSGTEHWWKIHEACMLALGSVKAIITDSVKNGRIHFDMHGFLTN
VILADLNLSVSPFLLGRALWAASRFTVAMSPELIQQFLQATVSGLHETQPPSVRISAVRA
IWGYCDQLKVSESTHVLQPFLPSILDGLIHLAAQFSSEVLNLVMETLCIVCTVDPEFTAS
MESKICPFTIAIFLKYSNDPVVASLAQDIFKELSQIEACQGPMQMRLIPTLVSIMQAPAD
KIPAGLCATAIDILTTVVRNTKPPLSQLLICQAFPAVAQCTLHTDDNATMQNGGECLRAY
VSVTLEQVAQWHDEQGHNGLWYVMQVVSQLLDPRTSEFTAAFVGRLVSTLISKAGRELGE
NLDQILRAILSKMQQAETLSVMQSLIMVFAHLVHTQLEPLLEFLCSLPGPTGKPALEFVM
AEWTSRQHLFYGQYEGKVSSVALCKLLQHGINADDKRLQDIRVKGEEIYSMDEGIRTRSK
SAKNPERWTNIPLLVKILKLIINELSNVMEANAARQATPAEWSQDDSNDMWEDQEEEEEE
EEDGLAGQLLSDILATSKYEEDYYEDDEEDDPDALKDPLYQIDLQAYLTDFLCQFAQQPC
YIMFSGHLNDNERRVLQTIGI

Primary citation

Importin-9 recognizes the winged-helix fold of ETS transcription factors to mediate nuclear import. McConville, M., Lankford, K., Bernardes, N.E. et al. Proc Natl Acad Sci U S A (2026) 123:e2536763123-e2536763123. DOI 10.1073/pnas.2536763123 · PubMed

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