1A6Z: Hfe (HUMAN) hemochromatosis protein

Hfe (HUMAN) hemochromatosis protein. Determined by X-ray diffraction at 2.6 Å resolution. Released 23 Mar 1999.

Method: X-ray diffraction
Resolution: 2.6 Å
Organism: Homo sapiens
Chains: 4
Atoms: 6,099
Mol. weight: 88.18 kDa
Released: 23 Mar 1999

Explore 1A6Z in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1A6Z contains 24 α-helices and 62 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A and C: 11 helices, 20 β-strands

Element	Residues	Length	Sheet
β-strand	6-15	10	1
β-strand	16	1	2
β-strand	23	1	2
β-strand	26-31	6	1
β-strand	34-40	7	1
β-strand	46-48	3	1
α-helix	61-85	25
β-strand	95-104	10	1
β-strand	110-118	9	1
β-strand	121-127	7	1
α-helix	128-130	3
β-strand	132-135	4	1
α-helix	138-140	3
α-helix	141-148	8
α-helix	152-159	8
α-helix	160-164	5
α-helix	165-176	12
β-strand	184	1	3
α-helix	185-186	2
β-strand	187-194	8	4
β-strand	199-208	10	4
β-strand	209	1	3
β-strand	214-219	6	5
β-strand	222-223	2	5
α-helix	226-228	3
α-helix	230-232	3
β-strand	233-236	4	4
β-strand	242-250	9	4
α-helix	254-257	4
β-strand	258-263	6	5
β-strand	271-274	4	5

Chains B and D: 1 helix, 11 β-strands

Element	Residues	Length	Sheet
β-strand	3	1	6
α-helix	4-5	2
β-strand	6-11	6	7
β-strand	21-30	10	7
β-strand	31	1	6
β-strand	35-41	7	8
β-strand	44-45	2	8
β-strand	50-51	2	7
β-strand	55-56	2	7
β-strand	62-70	9	7
β-strand	78-84	7	8
β-strand	91-94	4	8

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
HFE	A, C	protein	275	Homo sapiens	Q30201 (AlphaFold model)
Beta-2-microglobulin	B, D	protein	99	Homo sapiens	P61769 (AlphaFold model)

Sequence of entity 1 (A, C), FASTA

>1A6Z_1 HFE (chains A, C)
RLLRSHSLHYLFMGASEQDLGLSLFEALGYVDDQLFVFYDHESRRVEPRTPWVSSRISSQ
MWLQLSQSLKGWDHMFTVDFWTIMENHNHSKESHTLQVILGCEMQEDNSTEGYWKYGYDG
QDHLEFCPDTLDWRAAEPRAWPTKLEWERHKIRARQNRAYLERDCPAQLQQLLELGRGVL
DQQVPPLVKVTHHVTSSVTTLRCRALNYYPQNITMKWLKDKQPMDAKEFEPKDVLPNGDG
TYQGWITLAVPPGEEQRYTCQVEHPGLDQPLIVIW

Sequence of entity 2 (B, D), FASTA

>1A6Z_2 BETA-2-MICROGLOBULIN (chains B, D)
IQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDW
SFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM

Primary citation

Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor. Lebron, J.A., Bennett, M.J., Vaughn, D.E. et al. Cell (1998) 93:111-123. DOI 10.1016/S0092-8674(00)81151-4 · PubMed

Other PDB entries of the same protein (UniProt Q30201 (AlphaFold model), which also has an AlphaFold model), best resolution first:

1DE4 2.8 Å, Hemochromatosis protein hfe complexed with transferrin receptor

Browse structure collections

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