1AO7: HLA-a 0201

Complex between human T-cell receptor, viral peptide (TAX), and HLA-a 0201. Determined by X-ray diffraction at 2.6 Å resolution. Released 17 Sept 1997.

Method: X-ray diffraction
Resolution: 2.6 Å
Organisms: Homo sapiens, Human T-lymphotropic virus 1
Chains: 5
Atoms: 5,711
Mol. weight: 95.03 kDa
Ligands: EMC
Released: 17 Sept 1997

Explore 1AO7 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1AO7 contains 17 α-helices and 64 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 10 helices, 19 β-strands

Element	Residues	Length	Sheet
β-strand	3-12	10	1
α-helix	20	1
β-strand	21-27	7	1
β-strand	32-37	6	1
β-strand	46-47	2	1
α-helix	50-55	6
α-helix	57-84	28
β-strand	94-103	10	1
β-strand	109-118	10	1
β-strand	121-126	6	1
β-strand	133-135	3	1
α-helix	138-149	12
α-helix	152-161	10
α-helix	163-174	12
α-helix	176-179	4
β-strand	183	1	2
β-strand	188-195	8	3
β-strand	198-208	11	3
β-strand	209	1	2
β-strand	214-219	6	4
β-strand	222-223	2	4
α-helix	224-227	4
β-strand	229-230	2	3
α-helix	231-233	3
β-strand	234-235	2	3
β-strand	241-249	9	3
α-helix	253-256	4
β-strand	258-262	5	4
β-strand	270-273	4	4

Chain B: 2 helices, 11 β-strands

Element	Residues	Length	Sheet
β-strand	3	1	5
α-helix	4-5	2
β-strand	6-11	6	6
β-strand	21-30	10	6
β-strand	31	1	5
β-strand	36-41	6	7
β-strand	44-45	2	7
β-strand	50-51	2	6
α-helix	52-54	3
β-strand	55-56	2	6
β-strand	62-70	9	6
β-strand	78-83	6	7
β-strand	91-94	4	7

Chain D: 2 helices, 11 β-strands

Element	Residues	Length	Sheet
β-strand	3-5	3	8
β-strand	10-13	4	9
β-strand	18-24	7	8
β-strand	31-37	7	9
β-strand	44-49	6	9
β-strand	54-55	2	8
β-strand	62-67	6	8
β-strand	72-77	6	8
α-helix	82-84	3
β-strand	86-93	8	9
α-helix	103-104	2
β-strand	105-106	2	9
β-strand	110-115	6	9

Chain E: 3 helices, 23 β-strands

Element	Residues	Length	Sheet
β-strand	4-7	4	10
β-strand	10-14	5	11
β-strand	19-21	3	12
β-strand	22-25	4	10
β-strand	31-38	8	11
β-strand	42-51	10	11
β-strand	54-57	4	11
β-strand	65-67	3	12
β-strand	74	1	10
β-strand	77-79	3	12
α-helix	84-86	3
β-strand	88-95	8	11
α-helix	97-99	3
β-strand	107-108	2	11
β-strand	112-116A	6	11
β-strand	123	1	13
β-strand	126-127	2	14
β-strand	146-150	5	14
β-strand	153	1	13
β-strand	157-163	7	15
β-strand	166-168	3	15
β-strand	172-174	3	14
β-strand	191-196	6	14
α-helix	200-203	4
β-strand	209-216	8	15
β-strand	235-242	8	15

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
HLA-a 0201	A	protein	275	Homo sapiens	P04439 (AlphaFold model)
Beta-2 microglobulin	B	protein	100	Homo sapiens	P61769 (AlphaFold model)
Tax peptide	C	protein	9	Human T-lymphotropic virus 1	P14079
T cell receptor alpha	D	protein	204	Homo sapiens	A0A075B6T6 (AlphaFold model), P01848
T cell receptor beta	E	protein	245	Homo sapiens	P01850

Sequence of entity 1 (A), FASTA

>1AO7_1 HLA-A 0201 (chains A)
GSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYW
DGETRKVKAHSQTHRVDLGTLRGYYNQSEAGSHTVQRMYGCDVGSDWRFLRGYHQYAYDG
KDYIALKEDLRSWTAADMAAQTTKHKWEAAHVAEQLRAYLEGTCVEWLRRYLENGKETLQ
RTDAPKTHMTHHAVSDHEATLRCWALSFYPAEITLTWQRDGEDQTQDTELVETRPAGDGT
FQKWAAVVVPSGQEQRYTCHVQHEGLPKPLTLRWE

Sequence of entity 2 (B), FASTA

>1AO7_2 BETA-2 MICROGLOBULIN (chains B)
MIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKD
WSFYLLYCTEFTPTEKDEYACRVNHVTLSQPCIVKWDRDM

Sequence of entity 3 (C), FASTA

>1AO7_3 TAX PEPTIDE (chains C)
LLFGYPVYV

Sequence of entity 4 (D), FASTA

>1AO7_4 T CELL RECEPTOR ALPHA (chains D)
KEVEQNSGPLSVPEGAIASLNCTYSDRGSQSFFWYRQYSGKSPELIMSIYSNGDKEDGRF
TAQLNKASQYVSLLIRDSQPSDSATYLCAVTTDSWGKLQFGAGTQVVVTPDIQNPDPAVY
QLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKTVLDMRSMDFKSNSAVAWSNKSD
FACANAFNNSIIPEDTFFPSPESS

Sequence of entity 5 (E), FASTA

>1AO7_5 T CELL RECEPTOR BETA (chains E)
NAGVTQTPKFQVLKTGQSMTLQCAQDMNHEYMSWYRQDPGMGLRLIHYSVGAGITDQGEV
PNGYNVSRSTTEDFPLRLLSAAPSQTSVYFCASRPGLAGGRPEQYFGPGTRLTVTEDLKN
VFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVSTDPQPLKE
QPALNDSRYALSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEA
WGRAD

Ligands and cofactors

ID	Name	Formula	Copies
EMC	Ethyl mercury ion	C2 H5 Hg	2

Primary citation

Structure of the complex between human T-cell receptor, viral peptide and HLA-A2. Garboczi, D.N., Ghosh, P., Utz, U. et al. Nature (1996) 384:134-141. DOI 10.1038/384134a0 · PubMed

Other PDB entries of the same protein (UniProt P04439 (AlphaFold model), which also has an AlphaFold model), best resolution first:

3MRE 1.1 Å, Crystal Structure of MHC class I HLA-A2 molecule complexed with EBV bmlf1-280-288…
3D25 1.3 Å, Crystal structure of HA-1 minor histocompatibility antigen bound to human class I MHC…
3MRG 1.3 Å, Crystal Structure of MHC class I HLA-A2 molecule complexed with HCV NS3-1073-1081…
6JOZ 1.35 Å, Crystal structure of BRLF peptide from EBV in complex with HLA-A1101.
5C0G 1.37 Å, HLA-A02 carrying YLGGPDFPTI
5N1Y 1.39 Å, HLA-A02 carrying MVWGPDPLYV
1I4F 1.4 Å, Crystal structure of HLA-A*0201/MAGE-A4-peptide complex
1OGA 1.4 Å, A structural basis for immunodominant human T-cell receptor recognition.
3MRB 1.4 Å, Crystal Structure of MHC class I HLA-A2 molecule complexed with HCMV pp65-495-503…
3MRK 1.4 Å, Crystal Structure of MHC class I HLA-A2 molecule complexed with AFP137 nonapeptide
6J2A 1.4 Å, The structure of HLA-A*3003/NP44
1X7Q 1.45 Å, Crystal structure of HLA-A*1101 with sars nucleocapsid peptide

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1AO7 is part of these collections:

Antibodies and the immune system

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