1B3U: Protein

Crystal structure of constant regulatory domain of human PP2A, PR65ALPHA. Determined by X-ray diffraction at 2.3 Å resolution. Released 12 Apr 1999.

Method

X-ray diffraction

Resolution

2.3 Å

Organism

Homo sapiens

Chains

2

Atoms

9,869

Mol. weight

130.49 kDa

Released

12 Apr 1999

Explore 1B3U in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1B3U contains 127 α-helices and 0 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 62 helices, 0 β-strands

Molecules and chains

>1B3U_1 PROTEIN (PROTEIN PHOSPHATASE PP2A) (chains A, B)
AAADGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRSELLPFLTDTIYD
EDEVLLALAEQLGTFTTLVGGPEYVHCLLPPLESLATVEETVVRDKAVESLRAISHEHSP
SDLEAHFVPLVKRLAGGDWFTSRTSACGLFSVCYPRVSSAVKAELRQYFRNLCSDDTPMV
RRAAASKLGEFAKVLELDNVKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLLPQEDLE
ALVMPTLRQAAEDKSWRVRYMVADKFTELQKAVGPEITKTDLVPAFQNLMKDCEAEVRAA
ASHKVKEFCENLSADCRENVIMSQILPCIKELVSDANQHVKSALASVIMGLSPILGKDNT
IEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRL
AIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATSNLKKLVEKFGKEWAHAT
IIPKVLAMSGDPNYLHRMTTLFCINVLSEVCGQDITTKHMLPTVLRMAGDPVANVRFNVA
KSLQKIGPILDNSTLQSEVKPILEKLTQDQDVDVKYFAQEALTVLSLA

Primary citation

The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs. Groves, M.R., Hanlon, N., Turowski, P. et al. Cell (1999) 96:99-110. DOI 10.1016/S0092-8674(00)80963-0 · PubMed

Related structures

Other PDB entries of the same protein (UniProt P30153 (AlphaFold model), which also has an AlphaFold model), best resolution first:

• 4I5L 2.43 Å, Structural mechanism of trimeric PP2A holoenzyme involving PR70: insight for Cdc6…
• 8TWE 2.55 Å, Cryo-EM structure of the PP2A:B55-FAM122A complex, B55 body
• 2IE4 2.6 Å, Structure of the Protein Phosphatase 2A Core Enzyme Bound to okadaic acid
• 9C6B 2.6 Å, PP2A:B55-p107 substrate complex
• 8TWI 2.69 Å, Cryo-EM structure of the PP2A:B55-FAM122A complex, PP2Ac body
• 8U1X 2.7 Å, The structure of the PP2A-B56Delta holoenzyme mutant - E197K
• 9C7T 2.7 Å, PP2A:B55-Eya3 substrate complex
• 8TTB 2.77 Å, Cryo-EM structure of the PP2A:B55-ARPP19 complex
• 8SO0 2.8 Å, Cryo-EM structure of the PP2A:B55-FAM122A complex
• 2IE3 2.8 Å, Structure of the Protein Phosphatase 2A Core Enzyme Bound to Tumor-inducing Toxins
• 3C5W 2.8 Å, Complex between PP2A-specific methylesterase PME-1 and PP2A core enzyme
• 4I5N 2.8 Å, Structural mechanism of trimeric PP2A holoenzyme involving PR70: insight for Cdc6…

Browse structure collections

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