1FNU: Streptococcal pyrogenic exotoxin a
Structure of streptococcal pyrogenic exotoxin a. Determined by X-ray diffraction at 1.94 Å resolution. Released 17 Nov 2000.
- Method
- X-ray diffraction
- Resolution
- 1.94 Å
- Organism
- Streptococcus pyogenes phage T12
- Chains
- 4
- Atoms
- 7,934
- Mol. weight
- 105.13 kDa
- Ligands
- CD
- Released
- 17 Nov 2000
Explore 1FNU in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
1FNU contains 34 α-helices and 74 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 10 helices, 19 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 2-5 | 4 | |
| α-helix | 6-8 | 3 | |
| α-helix | 10-11 | 2 | |
| α-helix | 12-14 | 3 | |
| α-helix | 19-26 | 8 | |
| α-helix | 28-29 | 2 | |
| β-strand | 30-36 | 7 | 1 |
| β-strand | 39 | 1 | 2 |
| β-strand | 45-48 | 4 | 2 |
| β-strand | 52 | 1 | 3 |
| β-strand | 55 | 1 | 3 |
| β-strand | 57-61 | 5 | 2 |
| α-helix | 65-72 | 8 | |
| β-strand | 75-80 | 6 | 1 |
| β-strand | 83 | 1 | 2 |
| β-strand | 96-100 | 5 | 2 |
| β-strand | 103-105 | 3 | 1 |
| β-strand | 110-123 | 14 | 4 |
| β-strand | 126-137 | 12 | 4 |
| β-strand | 139-141 | 3 | 5 |
| α-helix | 142-157 | 16 | |
| β-strand | 161 | 1 | 6 |
| β-strand | 163 | 1 | 6 |
| β-strand | 169-176 | 8 | 4 |
| β-strand | 182-185 | 4 | 4 |
| α-helix | 194-197 | 4 | |
| α-helix | 198-201 | 4 | |
| β-strand | 206-208 | 3 | 5 |
| β-strand | 212-219 | 8 | 4 |
Chain B: 8 helices, 19 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 302-305 | 4 | |
| α-helix | 310-311 | 2 | |
| α-helix | 312-314 | 3 | |
| α-helix | 319-326 | 8 | |
| β-strand | 330-335 | 6 | 7 |
| β-strand | 339 | 1 | 8 |
| β-strand | 345-348 | 4 | 8 |
| β-strand | 352 | 1 | 9 |
| β-strand | 355 | 1 | 9 |
| β-strand | 357-361 | 5 | 8 |
| α-helix | 365-372 | 8 | |
| β-strand | 376-380 | 5 | 7 |
| β-strand | 383 | 1 | 8 |
| β-strand | 396-400 | 5 | 8 |
| β-strand | 403-405 | 3 | 7 |
| β-strand | 410-423 | 14 | 10 |
| β-strand | 426-437 | 12 | 10 |
| β-strand | 439-441 | 3 | 11 |
| α-helix | 442-456 | 15 | |
| β-strand | 461 | 1 | 12 |
| β-strand | 463 | 1 | 12 |
| β-strand | 467-475 | 9 | 10 |
| β-strand | 482-485 | 4 | 10 |
| α-helix | 494-497 | 4 | |
| α-helix | 498-501 | 4 | |
| β-strand | 506-508 | 3 | 11 |
| β-strand | 513-520 | 8 | 10 |
Chain C: 9 helices, 17 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 603-605 | 3 | |
| α-helix | 606-608 | 3 | |
| α-helix | 610-611 | 2 | |
| α-helix | 612-614 | 3 | |
| α-helix | 619-626 | 8 | |
| β-strand | 630-635 | 6 | 13 |
| β-strand | 639 | 1 | 14 |
| β-strand | 645-648 | 4 | 14 |
| β-strand | 652 | 1 | 15 |
| β-strand | 655 | 1 | 15 |
| β-strand | 657-661 | 5 | 14 |
| α-helix | 665-672 | 8 | |
| β-strand | 676-680 | 5 | 13 |
| β-strand | 683 | 1 | 14 |
| β-strand | 696-700 | 5 | 14 |
| β-strand | 703-705 | 3 | 13 |
| β-strand | 710-723 | 14 | 16 |
| β-strand | 726-737 | 12 | 16 |
| β-strand | 739-741 | 3 | 17 |
| α-helix | 742-757 | 16 | |
| β-strand | 769-775 | 7 | 16 |
| β-strand | 782-785 | 4 | 16 |
| α-helix | 794-797 | 4 | |
| α-helix | 798-801 | 4 | |
| β-strand | 806-808 | 3 | 17 |
| β-strand | 813-819 | 7 | 16 |
Chain D: 7 helices, 19 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 906-908 | 3 | |
| α-helix | 912-914 | 3 | |
| α-helix | 919-926 | 8 | |
| β-strand | 930-935 | 6 | 18 |
| β-strand | 939 | 1 | 19 |
| β-strand | 945-948 | 4 | 19 |
| β-strand | 952 | 1 | 20 |
| β-strand | 955 | 1 | 20 |
| β-strand | 957-961 | 5 | 19 |
| α-helix | 965-972 | 8 | |
| β-strand | 976-980 | 5 | 18 |
| β-strand | 983 | 1 | 19 |
| β-strand | 996-1000 | 5 | 19 |
| β-strand | 1003-1005 | 3 | 18 |
| β-strand | 1010-1023 | 14 | 21 |
| β-strand | 1026-1037 | 12 | 21 |
| β-strand | 1039-1041 | 3 | 22 |
| α-helix | 1042-1057 | 16 | |
| β-strand | 1061 | 1 | 23 |
| β-strand | 1063 | 1 | 23 |
| β-strand | 1069-1074 | 6 | 21 |
| β-strand | 1082-1085 | 4 | 21 |
| α-helix | 1094-1097 | 4 | |
| α-helix | 1098-1101 | 4 | |
| β-strand | 1106-1108 | 3 | 22 |
| β-strand | 1114-1119 | 6 | 21 |
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Exotoxin type A precursor (allele 1) | A, B, C, D | protein | 221 | Streptococcus pyogenes phage T12 | P0DJY8 |
Sequence of entity 1 (A, B, C, D), FASTA
>1FNU_1 EXOTOXIN TYPE A PRECURSOR (ALLELE 1) (chains A, B, C, D)
QQDPDPSQLHRSSLVKNLQNIYFLYEGDPVTHENVKSVDQLLSHDLIYNVSGPNYDKLKT
ELKNQEMATLFKDKNVDIYGVEYYHLCYLCENAERSACIYGGVTNHEGNHLEIPKKIVVK
VSIDGIQSLSFDIETNKKMVTAQELDYKVRKYTIDNKQLYTNGPSKYETGYIKFIPKNKE
SFWFDFFPEPEFTQSKYLMIYKDNETLDNKTSQIEVYLTTK
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| CD | Cadmium ion | Cd | 15 |
Primary citation
Structure of streptococcal pyrogenic exotoxin A reveals a novel metal cluster. Earhart, C.A., Vath, G.M., Roggiani, M. et al. Protein Sci (2000) 9:1847-1851. PubMed
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