1FSO: Truncated human rhogdi quadruple mutant

Crystal structure of truncated human rhogdi quadruple mutant. Determined by X-ray diffraction at 2.0 Å resolution. Released 2 May 2001.

Method: X-ray diffraction
Resolution: 2.0 Å
Organism: Homo sapiens
Chains: 1
Atoms: 1,304
Mol. weight: 15.83 kDa
Released: 2 May 2001

Explore 1FSO in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1FSO contains 3 α-helices and 11 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 3 helices, 11 β-strands

Element	Residues	Length	Sheet
β-strand	70-78	9	1
β-strand	87-89	3	1
α-helix	94-99	6
β-strand	102-105	4	2
β-strand	109-110	2	3
β-strand	111-118	8	1
β-strand	123-134	12	2
β-strand	137-149	13	2
β-strand	152-159	8	1
α-helix	160-162	3
β-strand	163-164	2	3
α-helix	169-171	3
β-strand	173-182	10	2
β-strand	188-199	12	2

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Rho GDP-dissociation inhibitor 1	A	protein	139	Homo sapiens	P52565 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>1FSO_1 RHO GDP-DISSOCIATION INHIBITOR 1 (chains A)
MVPNVVVTGLTLVCSSAPGPLELDLTGDLESFKKQSFVLKEGVEYRIKISFRVNREIVSG
MKYIQHTYRAGVAIDATDYMVGSYGPRAEEYEFLTPVEEAPKGMLARGSYSIKSRFTDDD
KTDHLSWEWNFTIKKDWKD

Primary citation

Protein crystallization by rational mutagenesis of surface residues: Lys to Ala mutations promote crystallization of RhoGDI. Longenecker, K.L., Garrard, S.M., Sheffield, P.J. et al. Acta Crystallogr D Biol Crystallogr (2001) 57:679-688. DOI 10.1107/S0907444901003122 · PubMed

Other PDB entries of the same protein (UniProt P52565 (AlphaFold model), which also has an AlphaFold model), best resolution first:

1KMT 1.3 Å, Crystal structure of RhoGDI Glu(154,155)Ala mutant
1QVY 1.6 Å, Crystal structure of RhoGDI K(199,200)R double mutant
2JHX 1.6 Å, Crystal structure of rhogdi E155H, E157H mutant
2JHU 1.65 Å, Crystal structure of rhogdi E154A,E155A mutant
2JHT 1.88 Å, Crystal structure of rhogdi K135T,K138T,K141T mutant
2JHY 1.9 Å, Crystal structure of rhogdi E155H, E157H mutant
2JHS 1.95 Å, Crystal structure of rhogdi K135H,K138H,K141H mutant
2JHV 2.07 Å, Crystal structure of rhogdi E154A,E155A mutant
2JI0 2.1 Å, Crystal structure of rhogdi K138Y, K141Y mutant
2JHZ 2.2 Å, Crystal structure of rhogdi E155S, E157S mutant
2BXW 2.4 Å, Crystal structure of rhogdi Lys(135,138,141)Tyr mutant
1RHO 2.5 Å, Structure of rho guanine nucleotide dissociation inhibitor

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