1G0U: Proteasome component Y7

A gated channel into the proteasome core particle. Determined by X-ray diffraction at 2.4 Å resolution. Released 6 Nov 2000.

Method: X-ray diffraction
Resolution: 2.4 Å
Organism: Saccharomyces cerevisiae
Chains: 28
Atoms: 51,834
Mol. weight: 718.94 kDa
Ligands: MG
Released: 6 Nov 2000

Explore 1G0U in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1G0U contains 236 α-helices and 392 β-strands across 28 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains 1 and M: 8 helices, 14 β-strands

Element	Residues	Length	Sheet
β-strand	-3--1	3	9
β-strand	3-8	6	10
β-strand	11-17	7	10
β-strand	20-22	3	9
β-strand	25-28	4	9
β-strand	34-36	3	9
β-strand	41-48	8	9
α-helix	49-67	19
α-helix	74-75	2
α-helix	76-92	17
β-strand	97-104	8	9
β-strand	108-114	7	9
β-strand	119-120	2	9
β-strand	124-126	3	10
α-helix	129-132	4
α-helix	134-138	5
α-helix	141D-145	6
α-helix	148-165	18
β-strand	166	1	57
β-strand	172-179	8	10
β-strand	183-191	9	10
α-helix	198-202	5

Chain 2: 7 helices, 13 β-strands

Element	Residues	Length	Sheet
β-strand	3-7	5	16
β-strand	11-16	6	16
β-strand	20-22	3	17
β-strand	25-28	4	17
β-strand	34-38	5	18
β-strand	41-47	7	18
α-helix	49-70	22
α-helix	74-75	2
α-helix	76-89	14
α-helix	91-94	3
β-strand	97-105	9	18
β-strand	107-113	7	18
β-strand	120-122	3	18
β-strand	124-127	4	16
α-helix	131-141	11
α-helix	148-165	18
β-strand	166	1	54
β-strand	173-179	7	16
β-strand	183-187B	7	16
α-helix	187D-187G	4

Chain A: 13 helices, 18 β-strands

Element	Residues	Length	Sheet
β-strand	11	1	1
β-strand	15-16	2	2
β-strand	20-21	2	2
α-helix	22-32	11
α-helix	35-36	2
β-strand	37-41	5	3
β-strand	46-51	6	3
β-strand	59	1	4
α-helix	61-63	3
β-strand	67-71	5	5
β-strand	74-80	7	5
α-helix	82-96	15
α-helix	97-101	5
α-helix	102-103	3
α-helix	106-108	3
α-helix	109-123	15
β-strand	127	1	1
β-strand	129	1	6
β-strand	134-142	9	5
β-strand	146-151	7	5
β-strand	157-159	3	5
β-strand	160	1	7
β-strand	162-165	4	3
α-helix	169-179	11
α-helix	186-200	15
β-strand	210-215	6	3
α-helix	217D-217F	3
β-strand	217I-217J	2	8
β-strand	221-223	3	3
α-helix	224-225	2
α-helix	226-233	8

Chain B: 11 helices, 15 β-strands

Element	Residues	Length	Sheet
β-strand	15	1	11
β-strand	21	1	11
α-helix	22-32	11
α-helix	35-36	2
β-strand	37-41	5	12
β-strand	45-51	7	12
α-helix	52	1
β-strand	59	1	7
β-strand	67-71	5	13
β-strand	74-80	7	13
α-helix	82-103	22
α-helix	106-108	3
α-helix	109-125	17
β-strand	126	1	14
β-strand	134-142	9	13
β-strand	145-151	7	13
β-strand	157-159	3	13
β-strand	160	1	15
β-strand	162-165	4	12
α-helix	169-179	11
α-helix	186-200	15
α-helix	207-209	3
β-strand	210-216	7	12
β-strand	220-223	4	12
α-helix	224-225	2
α-helix	226-235	10

Chain C: 11 helices, 15 β-strands

Element	Residues	Length	Sheet
β-strand	15	1	19
β-strand	21	1	19
α-helix	22-33	12
α-helix	35-36	2
β-strand	37-41	5	20
β-strand	46-51	6	20
α-helix	52-53	2
β-strand	59	1	15
β-strand	67-71	5	21
β-strand	74-80	7	21
α-helix	82-103	22
α-helix	106-108	3
α-helix	109-122	14
β-strand	129	1	14
α-helix	130-132	3
β-strand	134-141	8	21
β-strand	146-151	6	21
β-strand	157-159	3	21
β-strand	160	1	22
β-strand	162-165	4	20
α-helix	169-179	11
α-helix	186-201	16
β-strand	210-216	7	20
β-strand	220-223	4	20
α-helix	224-225	2
α-helix	226-241	16

Chains D and R: 13 helices, 13 β-strands

Element	Residues	Length	Sheet
α-helix	14	1
β-strand	15	1	23
α-helix	16	1
β-strand	21	1	23
α-helix	22-32	11
α-helix	35-36	2
β-strand	37-41	5	24
β-strand	46-51	6	24
β-strand	59	1	22
α-helix	61-63	3
β-strand	67-71	5	25
β-strand	74-80	7	25
α-helix	82-84	3
α-helix	85-103	19
α-helix	106-108	3
α-helix	109-120	12
β-strand	134-142	9	25
β-strand	145-151	7	25
β-strand	157-160	4	25
β-strand	162-165	4	24
α-helix	169-179	11
α-helix	186-200	15
β-strand	210-216	7	24
β-strand	220-223	4	24
α-helix	224-225	2
α-helix	226-241	15

Chain E: 9 helices, 12 β-strands

Element	Residues	Length	Sheet
α-helix	22-32	11
β-strand	37-41	5	26
β-strand	45-51	7	26
β-strand	59	1	25
β-strand	67-71	5	27
β-strand	74-80	7	27
α-helix	82-98	17
α-helix	99-103	5
α-helix	106-108	3
α-helix	109-122	14
β-strand	126	1	28
β-strand	134-142	9	27
β-strand	145-152	8	27
β-strand	156-160	5	27
β-strand	162-165	4	26
α-helix	170-180C	14
α-helix	186-197	12
α-helix	198-200	3
β-strand	210-216	7	26
β-strand	219-225	7	26
α-helix	226-232	7

Chains F and T: 9 helices, 13 β-strands

Element	Residues	Length	Sheet
α-helix	22-32	11
β-strand	37-41	5	29
β-strand	45-53	9	29
β-strand	59	1	27
α-helix	60	1
β-strand	68-70	3	30
β-strand	74-80	7	30
α-helix	82-103	22
α-helix	106-108	3
α-helix	109-122	14
β-strand	129	1	28
β-strand	134-142	9	30
β-strand	145-151	7	30
β-strand	157-159	3	30
β-strand	160	1	31
β-strand	162-165	4	29
α-helix	169-180B	14
α-helix	186-201	15
α-helix	202-205	4
β-strand	208-216	9	29
β-strand	221-223	3	29
α-helix	227-239	13

16 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Proteasome component Y7	A, O	protein	250	Saccharomyces cerevisiae	P23639 (AlphaFold model)
Proteasome component Y13	B, P	protein	245	Saccharomyces cerevisiae	P23638 (AlphaFold model)
Proteasome component PRE6	C, Q	protein	243	Saccharomyces cerevisiae	P40303 (AlphaFold model)
Proteasome component PUP2	D, R	protein	241	Saccharomyces cerevisiae	P32379 (AlphaFold model)
Proteasome component PRE5	E, S	protein	234	Saccharomyces cerevisiae	P40302
Proteasome component C1	F, T	protein	248	Saccharomyces cerevisiae	P21242
Proteasome component C7-alpha	G, U	protein	252	Saccharomyces cerevisiae	P21243
Proteasome component PUP1	H, V	protein	222	Saccharomyces cerevisiae	P25043
Proteasome component PUP3	I, W	protein	205	Saccharomyces cerevisiae	P25451
Proteasome component C11	J, X	protein	198	Saccharomyces cerevisiae	P22141
Proteasome component PRE2	K, Y	protein	212	Saccharomyces cerevisiae	P30656
Proteasome component C5	L, Z	protein	241	Saccharomyces cerevisiae	P23724

2 more molecules are not listed.

Sequence of entity 1 (A, O), FASTA

>1G0U_1 PROTEASOME COMPONENT Y7 (chains A, O)
MTDRYSFSLTTFSPSGKLGQIDYALTAVKQGVTSLGIKATNGVVIATEKKSSSPLAMSET
LSKVSLLTPDIGAVYSGMGPDYRVLVDKSRKVAHTSYKRIYGEYPPTKLLVSEVAKIMQE
ATQSGGVRPFGVSLLIAGHDEFNGFSLYQVDPSGSYFPWKATAIGKGSVAAKTFLEKRWN
DELELEDAIHIALLTLKESVEGEFNGDTIELAIIGDENPDLLGYTGIPTDKGPRFRKLTS
QEINDRLEAL

Sequence of entity 2 (B, P), FASTA

>1G0U_2 PROTEASOME COMPONENT Y13 (chains B, P)
MGSRRYDSRTTIFSPEGRLYQVEYALESISHAGTAIGIMASDGIVLAAERKVTSTLLEQD
TSTEKLYKLNDKIAVAVAGLTADAEILINTARIHAQNYLKTYNEDIPVEILVRRLSDIKQ
GYTQHGGLRPFGVSFIYAGYDDRYGYQLYTSNPSGNYTGWKAISVGANTSAAQTLLQMDY
KDDMKVDDAIELALKTLSKTTDSSALTYDRLEFATIRKGANDGEVYQKIFKPQEIKDILV
KTGIT

Sequence of entity 3 (C, Q), FASTA

>1G0U_3 PROTEASOME COMPONENT PRE6 (chains C, Q)
MSGYDRALSIFSPDGHIFQVEYALEAVKRGTCAVGVKGKNCVVLGCERRSTLKLQDTRIT
PSKVSKIDSHVVLSFSGLNADSRILIEKARVEAQSHRLTLEDPVTVEYLTRYVAGVQQRY
TQSGGVRPFGVSTLIAGFDPRDDEPKLYQTEPSGIYSSWSAQTIGRNSKTVREFLEKNYD
RKEPPATVEECVKLTVRSLLEVVQTGAKNIEITVVKPDSDIVALSSEEINQYVTQIEQEK
QEQ

Sequence of entity 4 (D, R), FASTA

>1G0U_4 PROTEASOME COMPONENT PUP2 (chains D, R)
MFLTRSEYDRGVSTFSPEGRLFQVEYSLEAIKLGSTAIGIATKEGVVLGVEKRATSPLLE
SDSIEKIVEIDRHIGCAMSGLTADARSMIEHARTAAVTHNLYYDEDINVESLTQSVCDLA
AAAAMSRPFGVALLIAGHDADDGYQLFHAEPSGTFYRYNAKAIGSGSEGAQAELLNEWHS
SLTLKEAELLVLKILKQVMEEKLDENNAQLSCITKQDGFKIYDNEKTAELIKELKEKEAA
E

Sequence of entity 5 (E, S), FASTA

>1G0U_5 PROTEASOME COMPONENT PRE5 (chains E, S)
MFRNNYDGDTVTFSPTGRLFQVEYALEAIKQGSVTVGLRSNTHAVLVALKRNADELSSYQ
KKIIKCDEHMGLSLAGLAPDARVLSNYLRQQCNYSSLVFNRKLAVERAGHLLCDKAQKNT
QSAGGRPYGVGLLIIGYDKSGAHLLEFQPSGNVTELYGTAIGARSQGAKTYLERTLDTFI
KIDGNPDELIKAGVEAISQSLRDESLTVDNLSIAIVGKDTPFTIYDGEAVAKYI

Sequence of entity 6 (F, T), FASTA

>1G0U_6 PROTEASOME COMPONENT C1 (chains F, T)
MTSIGTGYDLSNSVFSPDGRNFQVEYAVKAVENGTTSIGIKCNDGVVFAVEKLITSKLLV
PQKNVKIQVVDRHIGCVYSGLIPDGRHLVNRGREEAASFKKLYKTPIPIPAFADRLGQYV
QAHTLYNSVRPFGVSTIFGGVDKNGAHLYMLEPSGSYWGYKGAATGKGRQSAKAELEKLV
DHHPEGLSAREAVKQAAKIIYLAHEDNKEKDFELEISWCSLSETNGLHKFVKGDLLQEAI
DFAQKEIN

Sequence of entity 7 (G, U), FASTA

>1G0U_7 PROTEASOME COMPONENT C7-ALPHA (chains G, U)
MSGAAAASAAGYDRHITIFSPEGRLYQVEYAFKATNQTNINSLAVRGKDCTVVISQKKVP
DKLLDPTTVSYIFCISRTIGMVVNGPIPDARNAALRAKAEAAEFRYKYGYDMPCDVLAKR
MANLSQIYTQRAYMRPLGVILTFVSVDEELGPSIYKTDPAGYYVGYKATATGPKQQEITT
NLENHFKKSKIDHINEESWEKVVEFAITHMIDALGTEFSKNDLEVGVATKDKFFTLSAEN
IEERLVAIAEQD

Sequence of entity 8 (H, V), FASTA

>1G0U_8 PROTEASOME COMPONENT PUP1 (chains H, V)
TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIG
SNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTD
VGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEI
GKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICD

Sequence of entity 9 (I, W), FASTA

>1G0U_9 PROTEASOME COMPONENT PUP3 (chains I, W)
MSDPSSINGGIVVAMTGKDCVAIACDLRLGSQSLGVSNKFEKIFHYGHVFLGITGLATDV
TTLNEMFRYKTNLYKLKEERAIEPETFTQLVSSSLYERRFGPYFVGPVVAGINSKSGKPF
IAGFDLIGCIDEAKDFIVSGTASDQLFGMCESLYEPNLEPEDLFETISQALLNAADRDAL
SGWGAVVYIIKKDEVVKRYLKMRQD

Sequence of entity 10 (J, X), FASTA

>1G0U_10 PROTEASOME COMPONENT C11 (chains J, X)
MDIILGIRVQDSVILASSKAVTRGISVLKDSDDKTRQLSPHTLMSFAGEAGDTVQFAEYI
QANIQLYSIREDYELSPQAVSSFVRQELAKSIRSRRPYQVNVLIGGYDKKKNKPELYQID
YLGTKVELPYGAHGYSGFYTFSLLDHHYRPDMTTEEGLDLLKLCVQELEKRMPMDFKGVI
VKIVDKDGIRQVDDFQAQ

Sequence of entity 11 (K, Y), FASTA

>1G0U_11 PROTEASOME COMPONENT PRE2 (chains K, Y)
TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTMAGGAADCQFWETWLG
SQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGT
RLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHV
TEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG

Sequence of entity 12 (L, Z), FASTA

>1G0U_12 PROTEASOME COMPONENT C5 (chains L, Z)
MATIASEYSSEASNTPIEHQFNPYGDNGGTILGIAGEDFAVLAGDTRNITDYSINSRYEP
KVFDCGDNIVMSANGFAADGDALVKRFKNSVKWYHFDHNDKKLSINSAARNIQHLLYGKR
FFPYYVHTIIAGLDEDGKGAVYSFDPVGSYEREQCRAGGAAASLIMPFLDNQVNFKNQYE
PGTNGKVKKPLKYLSVEEVIKLVRDSFTSATERHIQVGDGLEILIVTKDGVRKEFYELKR
D

Ligands and cofactors

ID	Name	Formula	Copies
MG	Magnesium ion	Mg	20

Primary citation

A gated channel into the proteasome core particle. Groll, M., Bajorek, M., Kohler, A. et al. Nat Struct Biol (2000) 7:1062-1067. DOI 10.1038/80992 · PubMed

Other PDB entries of the same protein (UniProt P23639 (AlphaFold model), which also has an AlphaFold model), best resolution first:

1RYP 1.9 Å, Crystal structure of the 20S proteasome from yeast at 2.4 Å resolution
8RVQ 2.02 Å, 20S proteasome from pre1-1
4R17 2.1 Å, Ligand-induced aziridine-formation at subunit beta5 of the yeast 20S proteasome
8RVL 2.14 Å, Proteasomal late precursor complex from pre1-1
8U7U 2.16 Å, Proteasome 20S Core Particle from Beta 3 D205 deletion
1G65 2.25 Å, Crystal structure of epoxomicin:20s proteasome reveals a molecular basis for selectivity…
8RVP 2.28 Å, Proteasomal late precursor complex from pre1-1, state 2
4QVP 2.3 Å, yCP beta5-M45T mutant in complex with bortezomib
5CZ4 2.3 Å, Yeast 20S proteasome at 2.3 A resolution
6HWE 2.3 Å, Yeast 20S proteasome beta2-G45A mutant in complex with carfilzomib
9GBK 2.39 Å, Blm10-20S proteasome complex from pre1-1
3NZJ 2.4 Å, Crystal structure of yeast 20S proteasome in complex with ligand 2a

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