1JEQ: Ku Heterodimer

Crystal Structure of the Ku Heterodimer. Determined by X-ray diffraction at 2.7 Å resolution. Released 15 Aug 2001.

Method

X-ray diffraction

Resolution

2.7 Å

Organism

Homo sapiens

Chains

2

Atoms

8,633

Mol. weight

134.14 kDa

Released

15 Aug 2001

Explore 1JEQ in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1JEQ contains 56 α-helices and 54 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 29 helices, 28 β-strands

Molecules and chains

>1JEQ_1 KU70 (chains A)
MSGWESYYKTEGDEEAEEEQEENLEASGDYKYSGRDSLIFLVDASKAMFESQSEDELTPF
DMSIQCIQSVYISKIISSDRDLLAVVFYGTEKDKNSVNFKNIYVLQELDNPGAKRILELD
QFKGQQGQKRFQDMMGHGSDYSLSEVLWVCANLFSDVQFKMSHKRIMLFTNEDNPHGNDS
AKASRARTKAGDLRDTGIFLDLMHLKKPGGFDISLFYRDIISIAEDEDLRVHFEESSKLE
DLLRKVRAKETRKRALSRLKLKLNKDIVISVGIYNLVQKALKPPPIKLYRETNEPVKTKT
RTFNTSTGGLLLPSDTKRSQIYGSRQIILEKEETEELKRFDDPGLMLMGFKPLVLLKKHH
YLRPSLFVYPEESLVIGSSTLFSALLIKCLEKEVAALCRYTPRRNIPPYFVALVPQEEEL
DDQKIQVTPPGFQLVFLPFADDKRKMPFTEKIMATPEQVGKMKAIVEKLRFTYRSDSFEN
PVLQQHFRNLEALALDLMEPEQAVDLTLPKVEAMNKRLGSLVDEFKELVYPPDYNPEGKV
TKRKHDNEGSGSKRPKVEYSEEELKTHISKGTLGKFTVPMLKEACRAYGLKSGLKKQELL
EALTKHFQD

>1JEQ_2 KU80 (chains B)
MVRSGNKAAVVLCMDVGFTMSNSIPGIESPFEQAKKVITMFVQRQVFAENKDEIALVLFG
TDGTDNPLSGGDQYQNITVHRHLMLPDFDLLEDIESKIQPGSQQADFLDALIVSMDVIQH
ETIGKKFEKRHIEIFTDLSSRFSKSQLDIIIHSLKKCDISLQFFLPFSLGKEDGSGDRGD
GPFRLGGHGPSFPLKGITEQQKEGLEIVKMVMISLEGEDGLDEIYSFSESLRKLCVFKKI
ERHSIHWPCRLTIGSNLSIRIAAYKSILQERVKKTWTVVDAKTLKKEDIQKETVYCLNDD
DETEVLKEDIIQGFRYGSDIVPFSKVDEEQMKYKSEGKCFSVLGFCKSSQVQRRFFMGNQ
VLKVFAARDDEAAAVALSSLIHALDDLDMVAIVRYAYDKRANPQVGVAFPHIKHNYECLV
YVQLPFMEDLRQYMFSSLKNSKKYAPTEAQLNAVDALIDSMSLAKKDEKTDTLEDLFPTT
KIPNPRFQRLFQCLLHRALHPREPLPPIQQHIWNMLNPPAEVTTKSQIPLSKIKTLFPLI
EAKKKDQVTAQEIFQDNHEDGPTAK

Primary citation

Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair. Walker, J.R., Corpina, R.A., Goldberg, J. Nature (2001) 412:607-614. DOI 10.1038/35088000 · PubMed

Related structures

Other PDB entries of the same protein (UniProt P12956 (AlphaFold model), which also has an AlphaFold model), best resolution first:

• 8AG4 2.46 Å, Vaccinia C16 protein bound to Ku70/Ku80
• 1JEY 2.5 Å, Crystal Structure of the Ku heterodimer bound to DNA
• 3RZX 2.61 Å, Mouse importin alpha-Ku70 NLS peptide complex
• 7ZYG 2.68 Å, CryoEM structure of Ku heterodimer bound to DNA, PAXX and XLF
• 7ZVT 2.74 Å, CryoEM structure of Ku heterodimer bound to DNA
• 6ERH 2.8 Å, Complex of XLF and heterodimer Ku bound to DNA
• 7ZWA 2.8 Å, CryoEM structure of Ku heterodimer bound to DNA and PAXX
• 9CQ3 2.8 Å, The gap-filling complex with Pol mu engaged in the NHEJ pathway
• 9GYF 2.8 Å, Ku70/80 with PAXX peptide mutation K193R
• 9N81 2.8 Å, A gap-filling complex with Pol mu engaged in the NHEJ Pathway
• 6ERG 2.9 Å, Complex of XLF and heterodimer Ku bound to DNA
• 7Z87 2.91 Å, DNA-PK in the active state

Browse structure collections

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