P27(KIP1)/CYCLIN A/CDK2 complex. Determined by X-ray diffraction at 2.3 Å resolution. Released 29 Jul 1997.
Explore 1JSU in 3D Show helices and sheets RCSB PDB PDBe
1JSU contains 40 α-helices and 15 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 17-22 | 6 | 1 |
| β-strand | 29-36 | 8 | 1 |
| β-strand | 38 | 1 | 2 |
| β-strand | 43 | 1 | 2 |
| α-helix | 46-55 | 10 | |
| β-strand | 63 | 1 | 3 |
| β-strand | 66-71 | 6 | 1 |
| β-strand | 75-81 | 7 | 1 |
| β-strand | 85-86 | 2 | 3 |
| α-helix | 87-94 | 8 | |
| α-helix | 101-119 | 19 | |
| β-strand | 123-124 | 2 | 4 |
| α-helix | 130-132 | 3 | |
| β-strand | 133-135 | 3 | 3 |
| β-strand | 141-143 | 3 | 3 |
| β-strand | 150-151 | 2 | 4 |
| α-helix | 166-168 | 3 | |
| α-helix | 171-174 | 4 | |
| α-helix | 183-198 | 16 | |
| α-helix | 208-219 | 12 | |
| α-helix | 230-232 | 3 | |
| α-helix | 243-247 | 5 | |
| α-helix | 248-251 | 4 | |
| α-helix | 257-266 | 10 | |
| α-helix | 275-276 | 2 | |
| α-helix | 277-280 | 4 | |
| α-helix | 284-288 | 5 | |
| α-helix | 292-294 | 3 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 176-178 | 3 | |
| α-helix | 179-192 | 14 | |
| α-helix | 199-202 | 4 | |
| α-helix | 208-224 | 17 | |
| α-helix | 229-243 | 15 | |
| α-helix | 250-268 | 19 | |
| α-helix | 272-274 | 3 | |
| α-helix | 275-281 | 7 | |
| α-helix | 288-301 | 14 | |
| α-helix | 311-319 | 9 | |
| α-helix | 327-342 | 16 | |
| α-helix | 344-347 | 4 | |
| α-helix | 352-368 | 17 | |
| α-helix | 374-380 | 7 | |
| α-helix | 384-400 | 17 | |
| α-helix | 401-403 | 3 | |
| α-helix | 408-412 | 5 | |
| α-helix | 416-418 | 3 | |
| α-helix | 421-423 | 3 | |
| α-helix | 425-427 | 3 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 38-49 | 12 | |
| α-helix | 54-60 | 7 | |
| β-strand | 62-63 | 2 | 5 |
| β-strand | 68-69 | 2 | 5 |
| β-strand | 77-80 | 4 | 1 |
| α-helix | 86-89 | 4 | |
| α-helix | 90-92 | 3 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Cyclin-dependent kinase-2 | A | protein | 298 | Homo sapiens | P24941 (AlphaFold model) |
| Cyclin a | B | protein | 260 | Homo sapiens | P20248 (AlphaFold model) |
| P27 | C | protein | 84 | Homo sapiens | P46527 (AlphaFold model) |
>1JSU_1 CYCLIN-DEPENDENT KINASE-2 (chains A) MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
>1JSU_2 CYCLIN A (chains B) NEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETL HLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVL RMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLP SVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREK YKNSKYHGVSLLNPPETLNL
>1JSU_3 P27 (chains C) HPKPSACRNLFGPVDHEELTRDLEKHCRDMEEASQRKWNFDFQNHKPLEGKYEWQEVEKG SLPEFYYRPPRPPKGACKVPAQES
Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex. Russo, A.A., Jeffrey, P.D., Patten, A.K. et al. Nature (1996) 382:325-331. DOI 10.1038/382325a0 · PubMed
Other PDB entries of the same protein (UniProt P24941 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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