1K8K: Arp2/3 Complex
Crystal Structure of Arp2/3 Complex. Determined by X-ray diffraction at 2.0 Å resolution. Released 7 Dec 2001.
- Method
- X-ray diffraction
- Resolution
- 2.0 Å
- Organism
- Bos taurus
- Chains
- 7
- Atoms
- 15,326
- Mol. weight
- 224.23 kDa
- Released
- 7 Dec 2001
Explore 1K8K in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
1K8K contains 88 α-helices and 80 β-strands across 7 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 28 helices, 19 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 6-7 | 2 | |
| β-strand | 8-12 | 5 | 1 |
| β-strand | 16-21 | 6 | 1 |
| β-strand | 29-32 | 4 | 1 |
| β-strand | 35-37 | 3 | 2 |
| α-helix | 56-58 | 3 | |
| β-strand | 60-62 | 3 | 2 |
| α-helix | 63-66 | 4 | |
| β-strand | 73-75 | 3 | 2 |
| β-strand | 78-79 | 2 | 3 |
| β-strand | 82-83 | 2 | 3 |
| α-helix | 86-95 | 10 | |
| α-helix | 96-101 | 6 | |
| α-helix | 105-107 | 3 | |
| β-strand | 110-114 | 5 | 1 |
| α-helix | 120-127 | 8 | |
| α-helix | 128-133 | 6 | |
| β-strand | 138-143 | 6 | 1 |
| α-helix | 144-151 | 8 | |
| α-helix | 152-154 | 3 | |
| β-strand | 165-170 | 6 | 4 |
| β-strand | 175-181 | 7 | 4 |
| β-strand | 184-185 | 2 | 4 |
| α-helix | 187-189 | 3 | |
| β-strand | 191-193 | 3 | 4 |
| α-helix | 197-209 | 13 | |
| α-helix | 217-219 | 3 | |
| α-helix | 220-231 | 12 | |
| α-helix | 238-247 | 10 | |
| α-helix | 249-251 | 3 | |
| β-strand | 254-259 | 6 | 5 |
| β-strand | 266-271 | 6 | 5 |
| α-helix | 274-280 | 7 | |
| α-helix | 285-287 | 3 | |
| α-helix | 296-306 | 11 | |
| α-helix | 309-311 | 3 | |
| α-helix | 314-317 | 4 | |
| β-strand | 319-322 | 4 | 4 |
| α-helix | 324-326 | 3 | |
| α-helix | 331-353 | 23 | |
| α-helix | 360-363 | 4 | |
| β-strand | 367-368 | 2 | 4 |
| α-helix | 376-384 | 9 | |
| α-helix | 388-393 | 6 | |
| β-strand | 395-396 | 2 | 1 |
| α-helix | 397-403 | 7 | |
| α-helix | 405-409 | 5 | |
Chain B: 10 helices, 8 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 156-159 | 4 | 6 |
| β-strand | 164-167 | 4 | 6 |
| β-strand | 169-170 | 2 | 7 |
| β-strand | 173-174 | 2 | 7 |
| β-strand | 180-182 | 3 | 6 |
| α-helix | 186-199 | 14 | |
| α-helix | 210-220 | 11 | |
| α-helix | 227-236 | 10 | |
| β-strand | 242-245 | 4 | 8 |
| β-strand | 251-254 | 4 | 8 |
| α-helix | 257-260 | 4 | |
| α-helix | 262-265 | 4 | |
| α-helix | 268-271 | 4 | |
| α-helix | 278-288 | 11 | |
| α-helix | 294-298 | 5 | |
| β-strand | 302-304 | 3 | 6 |
| α-helix | 306-308 | 3 | |
| α-helix | 313-328 | 16 | |
Chain C: 6 helices, 30 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 3-5 | 3 | 9 |
| β-strand | 13-16 | 4 | 10 |
| β-strand | 22-26 | 5 | 10 |
| β-strand | 31-38 | 8 | 10 |
| β-strand | 41-49 | 9 | 10 |
| β-strand | 55-61 | 7 | 11 |
| β-strand | 66-71 | 6 | 11 |
| β-strand | 76-82 | 7 | 11 |
| β-strand | 85-91 | 7 | 11 |
| β-strand | 99-104 | 6 | 12 |
| β-strand | 110-115 | 6 | 12 |
| β-strand | 120-126 | 7 | 12 |
| β-strand | 131-137 | 7 | 12 |
| β-strand | 145-150 | 6 | 13 |
| β-strand | 156-161 | 6 | 13 |
| β-strand | 166-170 | 5 | 13 |
| α-helix | 180-182 | 3 | |
| β-strand | 183 | 1 | 14 |
| β-strand | 186 | 1 | 14 |
| β-strand | 194-197 | 4 | 13 |
| β-strand | 205-210 | 6 | 15 |
| β-strand | 216-221 | 6 | 15 |
| β-strand | 225-230 | 6 | 15 |
| α-helix | 231-233 | 3 | |
| β-strand | 236-241 | 6 | 15 |
| α-helix | 245-246 | 2 | |
| β-strand | 247-254 | 8 | 16 |
| β-strand | 257-262 | 6 | 16 |
| β-strand | 268-273 | 6 | 16 |
| β-strand | 278-281 | 4 | 16 |
| α-helix | 298-304 | 7 | |
| α-helix | 305-307 | 3 | |
| β-strand | 329-336 | 8 | 9 |
| β-strand | 344-349 | 6 | 9 |
| β-strand | 353-358 | 6 | 9 |
| α-helix | 359-365 | 7 | |
Chain D: 18 helices, 10 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 4-5 | 2 | |
| α-helix | 9-24 | 16 | |
| α-helix | 26-30 | 5 | |
| β-strand | 32-37 | 6 | 17 |
| β-strand | 41-46 | 6 | 17 |
| α-helix | 48-50 | 3 | |
| β-strand | 54-60 | 7 | 17 |
| α-helix | 64-68 | 5 | |
| α-helix | 72-80 | 9 | |
| α-helix | 81-83 | 3 | |
| β-strand | 84-85 | 2 | 17 |
| α-helix | 87-88 | 2 | |
| β-strand | 93-98 | 6 | 17 |
| α-helix | 106-114 | 9 | |
| α-helix | 116-134 | 19 | |
| α-helix | 139-141 | 3 | |
| β-strand | 142-147 | 6 | 18 |
| β-strand | 150-156 | 7 | 18 |
| β-strand | 161-168 | 8 | 18 |
| α-helix | 172-186 | 15 | |
| α-helix | 188-190 | 3 | |
| α-helix | 196 | 1 | |
| β-strand | 197-202 | 6 | 18 |
| α-helix | 207-209 | 3 | |
| β-strand | 220-227 | 8 | 18 |
| α-helix | 229-232 | 4 | |
| α-helix | 237-244 | 8 | |
| α-helix | 247-278 | 32 | |
Chain E: 9 helices, 6 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 14-16 | 3 | 19 |
| β-strand | 19-21 | 3 | 19 |
| β-strand | 24 | 1 | 20 |
| α-helix | 32-33 | 2 | |
| β-strand | 34 | 1 | 20 |
| α-helix | 35 | 1 | |
| α-helix | 41-52 | 12 | |
| α-helix | 63-82 | 20 | |
| α-helix | 88-100 | 13 | |
| α-helix | 118-120 | 3 | |
| α-helix | 123-148 | 26 | |
| β-strand | 149 | 1 | 21 |
| β-strand | 156 | 1 | 21 |
| α-helix | 158-161 | 4 | |
| α-helix | 168-170 | 3 | |
Chain F: 8 helices, 7 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 5-19 | 15 | |
| α-helix | 37-40 | 4 | |
| α-helix | 44-46 | 3 | |
| β-strand | 47 | 1 | 22 |
| α-helix | 48-50 | 3 | |
| β-strand | 51-54 | 4 | 23 |
| β-strand | 60-65 | 6 | 23 |
| β-strand | 66 | 1 | 22 |
| β-strand | 69-75 | 7 | 23 |
| α-helix | 81-96 | 16 | |
| β-strand | 104 | 1 | 23 |
| α-helix | 108-109 | 2 | |
| β-strand | 114-119 | 6 | 23 |
| α-helix | 120-125 | 6 | |
| α-helix | 128-165 | 38 | |
Chain G: 9 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 10-12 | 3 | |
| α-helix | 16-19 | 4 | |
| α-helix | 39-47 | 9 | |
| α-helix | 51-58 | 8 | |
| α-helix | 69-85 | 17 | |
| α-helix | 88-90 | 3 | |
| α-helix | 91-96 | 6 | |
| α-helix | 100-114 | 15 | |
| α-helix | 121-145 | 25 | |
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Actin-like protein 3 | A | protein | 418 | Bos taurus | P61157 (AlphaFold model) |
| Actin-like protein 2 | B | protein | 394 | Bos taurus | A7MB62 (AlphaFold model) |
| ARP2/3 complex 41 kda subunit | C | protein | 372 | Bos taurus | Q58CQ2 (AlphaFold model) |
| ARP2/3 complex 34 kda subunit | D | protein | 300 | Bos taurus | Q3MHR7 (AlphaFold model) |
| ARP2/3 complex 21 kda subunit | E | protein | 178 | Bos taurus | Q3T035 |
| ARP2/3 complex 20 kda subunit | F | protein | 168 | Bos taurus | Q148J6 |
| ARP2/3 complex 16 kda subunit | G | protein | 151 | Bos taurus | Q3SYX9 |
Sequence of entity 1 (A), FASTA
>1K8K_1 ACTIN-LIKE PROTEIN 3 (chains A)
MAGRLPACVVDCGTGYTKLGYAGNTEPQFIIPSCIAIKESAKVGDQAQRRVMKGVDDLDF
FIGDEAIEKPTYATKWPIRHGIVEDWDLMERFMEQVIFKYLRAEPEDHYFLLTEPPLNTP
ENREYTAEIMFESFNVPGLYIAVQAVLALAASWTSRQVGERTLTGTVIDSGDGVTHVIPV
AEGYVIGSCIKHIPIAGRDITYFIQQLLRDREVGIPPEQSLETAKAVKERYSYVCPDLVK
EFNKYDTDGSKWIKQYTGINAISKKEFSIDVGYERFLGPEIFFHPEFANPDFTQPISEVV
DEVIQNCPIDVRRPLYKNIVLSGGSTMFRDFGRRLQRDLKRTVDARLKLSEELSGGRLKP
KPIDVQVITHHMQRYAVWFGGSMLASTPEFYQVCHTKKDYEEIGPSICRHNPVFGVMS
Sequence of entity 2 (B), FASTA
>1K8K_2 ACTIN-LIKE PROTEIN 2 (chains B)
MDSQGRKVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRSTTKVGNIEIKDLMVGDE
ASELRSMLEVNYPMENGIVRNWDDMKHLWDYTFGPEKLNIDTRNCKILLTEPPMNPTKNR
EKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSGDGVTHICPVYEGFSLPHLTR
RLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYVGYNIEQEQKLALETTVL
VESYTLPDGRIIKVGGERFEAPEALFQPHLINVEGVGVAELLFNTIQAADIDTRSEFYKH
IVLSGGSTMYPGLPSRLERELKQLYLERVLKGDVEKLSKFKIRIEDPPRRKHMVFLGGAV
LADIMKDKDNFWMTRQEYQEKGVRVLEKLGVTVR
Sequence of entity 3 (C), FASTA
>1K8K_3 ARP2/3 COMPLEX 41 KDA SUBUNIT (chains C)
MAYHSFLVEPISCHAWNKDRTQIAICPNNHEVHIYEKSGNKWVQVHELKEHNGQVTGVDW
APDSNRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNEKKFAVGSGSRVI
SICYFEQENDWWVCKHIKKPIRSTVLSLDWHPNSVLLAAGSCDFKCRIFSAYIKEVEERP
APTPWGSKMPFGELMFESSSSCGWVHGVCFSANGSRVAWVSHDSTVCLADADKKMAVATL
ASETLPLLAVTFITESSLVAAGHDCFPVLFTYDSAAGKLSFGGRLDVPKQSSQRGLTARE
RFQNLDKKASSEGSAAAGAGLDSLHKNSVSQISVLSGGKAKCSQFCTTGMDGGMSIWDVR
SLESALKDLKIV
Sequence of entity 4 (D), FASTA
>1K8K_4 ARP2/3 COMPLEX 34 KDA SUBUNIT (chains D)
MILLEVNNRIIEETLALKFENAAAGNKPEAVEVTFADFDGVLYHISNPNGDKTKVMVSIS
LKFYKELQAHGADELLKRVYGSYLVNPESGYNVSLLYDLENLPASKDSIVHQAGMLKRNC
FASVFEKYFQFQEEGKEGENRAVIHYRDDETMYVESKKDRVTVVFSTVFKDDDDVVIGKV
FMQEFKEGRRASHTAPQVLFSHREPPLELKDTDAAVGDNIGYITFVLFPRHTNASARDNT
INLIHTFRDYLHYHIKCSKAYIHTRMRAKTSDFLKVLNRARPDAEKKEMKTITGKTFSSR
Sequence of entity 5 (E), FASTA
>1K8K_5 ARP2/3 COMPLEX 21 KDA SUBUNIT (chains E)
MPAYHSSLMDPDTKLIGNMALLPIRSQFKGPAPRETKDTDIVDEAIYYFKANVFFKNYEI
KNEADRTLIYITLYISECLKKLQKCNSKSQGEKEMYTLGITNFPIPGEPGFPLNAIYAKP
ANKQEDEVMRAYLQQLRQETGLRLCEKVFDPQNDKPSKWWTCFVKRQFMNKSLSGPGQ
Sequence of entity 6 (F), FASTA
>1K8K_6 ARP2/3 COMPLEX 20 KDA SUBUNIT (chains F)
MTATLRPYLSAVRATLQAALCLENFSSQVVERHNKPEVEVRSSKELLLQPVTISRNEKEK
VLIEGSINSVRVSIAVKQADEIEKILCHKFMRFMMMRAENFFILRRKPVEGYDISFLITN
FHTEQMYKHKLVDFVIHFMEEIDKEISEMKLSVNARARIVAEEFLKNF
Sequence of entity 7 (G), FASTA
>1K8K_7 ARP2/3 COMPLEX 16 KDA SUBUNIT (chains G)
MSKNTVSSARFRKVDVDEYDENKFVDEDDGGDGQAGPDEGEVDSCLRQGNMTAALQAALK
NPPINTKSQAVKDRAGSIVLKVLISFKANDIEKAVQSLDKNGVDLLMKYIYKGFESPSDN
SSAVLLQWHEKALAAGGVGSIVRVLTARKTV
Primary citation
Crystal Structure of Arp2/3 Complex. Robinson, R.C., Turbedsky, K., Kaiser, D.A. et al. Science (2001) 294:1679-1684. DOI 10.1126/science.1066333 · PubMed
Other PDB entries of the same protein (UniProt P61157 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 2P9I 2.46 Å, Crystal Structure of bovine Arp2/3 Complex co-crystallized with ADP and crosslinked with…
- 3UKR 2.48 Å, Crystal structure of Bos taurus Arp2/3 complex with bound inhibitor CK-666
- 3ULE 2.5 Å, Structure of Bos taurus Arp2/3 complex with bound inhibitor CK-869 and ATP
- 1TYQ 2.55 Å, Crystal structure of Arp2/3 complex with bound ATP and calcium
- 1U2V 2.55 Å, Crystal structure of Arp2/3 complex with bound ADP and calcium
- 2P9K 2.59 Å, Crystal structure of bovine Arp2/3 complex co-crystallized with ATP and crosslinked with…
- 2P9L 2.65 Å, Crystal Structure of bovine Arp2/3 complex
- 3RSE 2.65 Å, Structural and biochemical characterization of two binding sites for nucleation…
- 2P9S 2.68 Å, Structure of bovine Arp2/3 complex co-crystallized with ATP/Mg2+
- 3DXK 2.7 Å, Structure of Bos Taurus Arp2/3 Complex with Bound Inhibitor CK0944636
- 2P9U 2.75 Å, Crystal structure of bovine Arp2/3 complex co-crystallized with AMP-PNP and calcium
- 3UKU 2.75 Å, Structure of Arp2/3 complex with bound inhibitor CK-869
Browse structure collections
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