1MLA: PDB entry 1MLA

The escherichia coli malonyl-coa:acyl carrier protein transacylase at 1.5-Å resolution. Crystal structure of a fatty acid synthase component. Determined by X-ray diffraction at 1.5 Å resolution. Released 8 Mar 1996.

Method: X-ray diffraction
Resolution: 1.5 Å
Organism: Escherichia coli
Chains: 1
Atoms: 2,408
Mol. weight: 32.44 kDa
Released: 8 Mar 1996

Explore 1MLA in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1MLA contains 17 α-helices and 12 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 17 helices, 12 β-strands

Element	Residues	Length	Sheet
β-strand	4-8	5	1
α-helix	20-25	6
α-helix	27-40	14
α-helix	44-50	7
α-helix	53-56	4
α-helix	59-79	21
α-helix	82-85	4
β-strand	87-90	4	1
α-helix	93-101	9
α-helix	107-124	18
β-strand	130-136	7	2
α-helix	140-150	11
β-strand	156-163	8	2
β-strand	166-172	7	2
α-helix	173-185	13
β-strand	190-193	4	2
α-helix	194	1
α-helix	203-205	3
α-helix	206-217	12
β-strand	228	1	1
β-strand	229	1	3
β-strand	236	1	3
α-helix	240-252	13
β-strand	255-256	2	2
α-helix	257-266	10
β-strand	271-274	4	1
α-helix	280-288	9
β-strand	293-296	4	1
α-helix	300-306	7

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Malonyl-coenzyme a acyl carrier protein transacylase	A	protein	309	Escherichia coli	P0AAI9 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>1MLA_1 MALONYL-COENZYME A ACYL CARRIER PROTEIN TRANSACYLASE (chains A)
MTQFAFVFPGQGSQTVGMLADMAASYPIVEETFAEASAALGYDLWALTQQGPAEELNKTW
QTQPALLTASVALYRVWQQQGGKAPAMMAGHSLGEYSALVCAGVIDFADAVRLVEMRGKF
MQEAVPEGTGAMAAIIGLDDASIAKACEEAAEGQVVSPVNFNSPGQVVIAGHKEAVERAG
AACKAAGAKRALPLPVSVPSHCALMKPAADKLAVELAKITFNAPTVPVVNNVDVKCETNG
DAIRDALVRQLYNPVQWTKSVEYMAAQGVEHLYEVGPGKVLTGLTKRIVDTLTASALNEP
SAMAAALEL

Primary citation

The Escherichia coli malonyl-CoA:acyl carrier protein transacylase at 1.5-A resolution. Crystal structure of a fatty acid synthase component. Serre, L., Verbree, E.C., Dauter, Z. et al. J Biol Chem (1995) 270:12961-12964. DOI 10.1074/jbc.270.22.12961 · PubMed

Other PDB entries of the same protein (UniProt P0AAI9 (AlphaFold model), which also has an AlphaFold model), best resolution first:

2G2O 1.76 Å, Structure of E.coli FabD complexed with sulfate
2G1H 1.86 Å, Structure of E.coli FabD complexed with glycerol
6U0J 1.9 Å, Crosslinked Crystal Structure of Malonyl-CoA Acyl Carrier Protein Transacylase, FabD,…
2G2Y 2.26 Å, Structure of E.coli FabD complexed with malonate
2G2Z 2.8 Å, Structure of E.coli FabD complexed with malonyl-CoA

Browse structure collections

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